OBJECTIVE Motor Unit Number Index (MUNIX) is a quantitative neurophysiological measure that provides an index of the number of lower motor neurons supplying a muscle. It reflects the loss of motor neurons in patients with Amyotrophic Lateral Sclerosis (ALS). However, it is unclear whether MUNIX also detects motor unit loss in strong, non-wasted muscles. METHODS Three centres measured MUNIX in...

The respiratory muscles have been studied extensively during the last 20 yrs. This interest was triggered predominantly by the observation made by ROUSSOS and MACKLEM [1] that the respiratory muscles, like all other skeletal muscles, may fatigue. Subsequent research critically examined the significance of inspiratory muscle fatigue in clinical pulmonary medicine. The conclusion of this research...

STUDY DESIGN Single-center retrospective study. PURPOSE To clarify the clinical features of cervical myelopathy at the C1-2 level. OVERVIEW OF LITERATURE Methods for distinguishing the affected level based on myelomere symptoms or dysfunction of the conducting pathway were established. However, no symptoms have been identified as being specific to the C1-2 level segment. METHODS We evalua...

Cancer-associated muscle dysfunction represents a deadly clinical problem, for which there is currently no treatment. Normal bone remodeling can be disrupted by tumor cells that metastasize to bone in certain stages of cancer, which results in increased morbidity including muscle weakness. The reason for this muscle weakness may be attributed to a reduction in muscle mass and/or a reduction in ...

Paraneoplastic syndromes (PNS) are defined as clinical syndromes caused by systemic effects of malignancy that are not due to direct physical effects of metastasis. The pathophysiology of PNS is not fully understood; it may result from antibodies against tumors that cross-react with normal tissues, causing injury, or injury induced by humoral factors secreted by tumor cells. PNS may fall into 1...