نتایج جستجو برای: muscarinic

تعداد نتایج: 9034  

Journal: :Brain research 2012
Hiroaki Norimoto Mika Mizunuma Daisuke Ishikawa Norio Matsuki Yuji Ikegaya

Cholinergic muscarinic innervations to the hippocampus play a role in learning and memory. Here we report that pharmacological activation of muscarinic receptors eliminates sharp wave-ripple events in the mouse hippocampal CA1 region in vivo and in vitro. This effect was associated with a decorrelation of excitatory synaptic inputs and a net increase in inhibitory conductances in pyramidal neur...

2017
Eleanor D. Muise Neeru Gandotra John J. Tackett Michaela C. Bamdad Robert A. Cowles

The data presented in this article are related to the research article entitled "Distribution of muscarinic acetylcholine receptor subtypes in the murine small intestine" (E.D. Muise, N. Gandotra, J.J. Tackett, M.C. Bamdad, R.A. Cowles, 2016) [1]. We recently demonstrated that neuronal serotonin stimulates intestinal crypt cell division, and induces villus growth and crypt depth (E.R. Gross, M....

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2004
Ha-Van Nguyen Alan Stuart-Tilley Seth L Alper James E Melvin

Large volumes of saliva are generated by transepithelial Cl(-) movement during parasympathetic muscarinic receptor stimulation. To gain further insight into a major Cl(-) uptake mechanism involved in this process, we have characterized the anion exchanger (AE) activity in mouse serous parotid and mucous sublingual salivary gland acinar cells. The AE activity in acinar cells was Na(+) independen...

2014
Patrik Aronsson Renata Vesela Martin Johnsson Yasin Tayem Vladimir Wsol Michael Winder Gunnar Tobin

Nitric oxide (NO) has pivotal roles in cyclophosphamide- (CYP-) induced cystitis during which mucosal nitric oxide synthase (NOS) and muscarinic M5 receptor expressions are upregulated. In cystitis, urothelial muscarinic NO-linked effects hamper contractility. Therefore we wondered if a blockade of this axis also affects the induction of cystitis in the rat. Rats were pretreated with saline, th...

2017
Sophie J. Bradley Julie-Myrtille Bourgognon Helen E. Sanger Nicholas Verity Adrian J. Mogg David J. White Adrian J. Butcher Julie A. Moreno Colin Molloy Timothy Macedo-Hatch Jennifer M. Edwards Jurgen Wess Robert Pawlak David J. Read Patrick M. Sexton Lisa M. Broad Joern R. Steinert Giovanna R. Mallucci Arthur Christopoulos Christian C. Felder Andrew B. Tobin

The current frontline symptomatic treatment for Alzheimer's disease (AD) is whole-body upregulation of cholinergic transmission via inhibition of acetylcholinesterase. This approach leads to profound dose-related adverse effects. An alternative strategy is to selectively target muscarinic acetylcholine receptors, particularly the M1 muscarinic acetylcholine receptor (M1 mAChR), which was previo...

Journal: :The Journal of pharmacology and experimental therapeutics 1999
R Maggio P Barbier A Colelli F Salvadori G Demontis G U Corsini

By means of the expression of two chimeric receptors, alpha(2)/M(3) and M(3)/alpha(2), in which the carboxy-terminal receptor portions, containing transmembrane domains VI and VII, were exchanged between the alpha(2C)-adrenergic and the M(3) muscarinic receptor, it has been shown that G protein-coupled receptors are able to interact functionally with each other at the molecular level to form (h...

Journal: :The Journal of biological chemistry 1988
R A Shapiro N M Scherer B A Habecker E M Subers N M Nathanson

A genomic clone encoding the gene for the mouse M1 muscarinic acetylcholine receptor has been isolated, placed under the control of the zinc-inducible mouse metallothionein promoter, and transfected into mouse Y1 adrenal cells. The receptor concentration was about 300 fmol/mg membrane protein in the absence of zinc and could be increased to 4000 fmol/mg membrane protein in the presence of incre...

Journal: :The Journal of pharmacology and experimental therapeutics 1997
H E Shannon M J Sheardown F P Bymaster D O Calligaro N W Delapp J Gidda C H Mitch B D Sawyer P W Stengel J S Ward D T Wong P H Olesen P D Suzdak P Sauerberg M D Swedberg

Butylthio[2.2.2], ((+)-(S)-3-(4-butylthio-1,2,5-thiadiazol-3-yl)-1-azabicyclo[2.2.2] octane; LY297802/NNC11-1053) is a muscarinic receptor ligand which is equiefficacious to morphine in producing antinociception. In vitro, butylthio[2.2.2] had high affinity for muscarinic receptors in brain homogenates, but had substantially less or no affinity for several other neurotransmiter receptors and up...

Journal: :Journal of neurophysiology 2014
Abigail Kalmbach Jack Waters

Release of acetylcholine (ACh) in neocortex is important for learning, memory and attention tasks. The primary source of ACh in neocortex is axons ascending from the basal forebrain. Release of ACh from these axons evokes changes in the cortical local field potential (LFP), including a decline in low-frequency spectral power that is often referred to as desynchronization of the LFP and is thoug...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1999
A R McQuiston D V Madison

Cholinergic input to the hippocampus may be involved in important behavioral functions and the pathophysiology of neurodegenerative diseases. Muscarinic receptor activity in interneurons of the hippocampus may play a role in these actions. In this study, we investigated the effects of muscarinic receptor activity on the excitability of different subtypes of interneurons in rat hippocampal CA1. ...

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