OBJECTIVES This study aimed to develop a novel type 2 diabetes model designated the HND (Horio-Niki diabetic) mouse, by transferring diabetogenic genes from wild castaneus mice (Mus musculus castaneus) captured in the Philippines into laboratory mice (C57BL/6J:B6). METHODS Offspring from the cross between a wild male and a B6 female were backcrossed to the sire. One male backcross which exhib...

X chromosome inactivation (XCI) is the mammalian mechanism of dosage compensation that balances X-linked gene expression between the sexes. Early during female development, each cell of the embryo proper independently inactivates one of its two parental X-chromosomes. In mice, the choice of which X chromosome is inactivated is affected by the genotype of a cis-acting locus, the X-chromosome con...

In recent years, it has become clear that all of the organisms on the Earth are related to each other in ways that can be documented by molecular sequence comparison. In this review, we focus on the evolutionary relationships among the proteins of the eukaryotes, especially those that allow inference of function from one species to another. Data and illustrations are derived from specific compa...

Hybrid sterility in the heterogametic sex is a common feature of speciation in animals. In house mice, the contribution of the Mus musculus musculus X chromosome to hybrid male sterility is large. It is not known, however, whether F1 male sterility is caused by X-Y or X-autosome incompatibilities or a combination of both. We investigated the contribution of the M. musculus domesticus Y chromoso...

McCluskie (1930), Robertson (1930), Francis (1936), and Knowles, Das Gupta and Sen (1936) have noted the occurrence of Spirillum minus in the naturally-infected mouse, Mus musculus. The last-named workers cited an incident in which a wrong diagnosis of rat-bite fever was established on the basis of discovery of spirilla in a white mouse inoculated with the blood of a patient suffering from prol...

Mitochondrial DNA from an Old World mouse, Mus musculus, and from an Old World rat, Rattus norvegicus, contain 19 and 22 distinct sites, respectively, for the 8 restriction endonucleases, BamHI, EcoRI, HaeII, HhaI, HincII, HindIII, HpaI and PstI. The relative positions of the sites have been mapped by the study of partial and double enzyme digests. Some sites may been conserverd between the mou...