Simulation models are a powerful tool to overcome gaps of evidence needed inform medical decision-making. Here, we present development and application COSIMO, Markov-based Colorectal Cancer (CRC) Multi-state Model simulate effects CRC screening, along with thorough assessment the model's ability reproduce real-life outcomes. Firstly, provide comprehensive documentation COSIMO’s development, str...

Methods During 2009, 167 MRSA-infected and 25766 MRSAuninfected control patients were included in a multistate model where occurrence of MRSA infection was the time-dependent exposure and discharge or death was the study endpoint. Infections were stratified by anatomical site. Excess LoS was extracted computing the Aalen-Johansen estimator of the matrix of transition probabilities. 95% confiden...

Signal transduction is an important and basic mechanism to cell life activities. The stochastic state transition of receptor induces the release signaling molecular, which triggers other receptors. It constructs a nonlinear sigaling network, leads robust switchlike properties are critical biological function. Network architectures transitions affect performance this network. In work, we perform...

We report the first measurement of the dynamics of bubble formation in double-stranded DNA. Fluctuations of fluorescence of a synthetic DNA construct, internally tagged with a fluorophore and a quencher, are monitored by fluorescence correlation spectroscopy. The relaxation dynamics follow a multistate relaxation kinetics, with a characteristic time scale of 50 microseconds. A simple model of b...

Quantification of energetics and kinetics for the band-edge exciton states of quantum dots and the long-lived dark state is important for better understanding of the underlying mechanism for single-particle intermittency and ensemble fluorescence intensity decay. Based on a multistate diffusion-reaction model by extending our previous studies, we analyze experimental data from ensemble measurem...

We use a multipath (multistate) model to describe data with multiple end points. Statistical inference based on the intermediate end point is challenging because of the problems of nonidentifiability and dependent censoring. We study nonparametric estimation for the path probability and the sojourn time distributions between the states. The methodology proposed can be applied to analyse cure mo...

The multistate life table (MSLT) model is an important demographic method to document life cycle processes. In this paper, we present the SPACE (Stochastic Population Analysis for Complex Events) program to estimate MSLT functions and their sampling variability. It has several advantages over other programs, including the use of micro-simulation and the bootstrap method to estimate the variance...

OBJECTIVE We assessed salience of subjective memory complaints (SMCs) by older individuals as a predictor of subsequent cognitive impairment while accounting for risk factors and eventual neuropathologies. METHODS Subjects (n = 531) enrolled while cognitively intact at the University of Kentucky were asked annually if they perceived changes in memory since their last visit. A multistate model...