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background: little in known regarding the clinical relevance of sirt1 in multiple sclerosis (ms).   here, we aimed to evaluate mrna expression, protein level and enzyme activity of sirt1 in peripheral blood mononuclear cells (pbmcs) isolated from relapsing –remitting ms patients (rrms) and healthy controls. materials and methods: twenty patients with rr-ms and twenty two age- and sex-matched he...

background: neurobrucellosis is a rare complication of brucellosis. acute meningitis and encephalitis are the most common clinical manifestations; however, symptoms of these two conditions may be subacute and diagnosis requires a high index of suspicion in patients from endemic areas. diagnosis is often based on neurological symptoms, serology, and suggestive brain imaging because cerebrospinal...

conclusions the orem-based self-care model program can be a useful tool to improve sleep quality of patients with ms. future studies can be directed to investigate the effects of such interventions on other common problems of patients. results before the intervention, there was no significant difference between the two groups with regard to mean scores of sleep quality (p = 0.22). both groups r...

multiple sclerosis (m.s) is one of the prevalent diseases of the central nervous system which cause disability in young adults. this appears as neural signs in different parts and various times. the main defect is local deterioration or destruction of myelin tissue in the brain and spinal cord. profound fatigue is one the most common symptoms of this disease. because ms is prevalent in middle a...

abstract objective: according to the previous studies, 2-5 percent of patients with multiple sclerosis experienced the first episode of disease before the age 16.  since the age of onset among children is not similar to that in general population, clinicians often fail to early diagnose the disease. this study aims to determine the epidemiological and clinical patterns of ms among iranian child...

a bstract       background:  patients with multiple sclerosis experience hospitalization several times in their lives. certainly, providing ef fi cient and high-quality care by healthcare professionals is not possible unless the experiences of patients’ hospitalization are taken into consideration. this qualitative study was aimed to identify experiences of patients with multiple sclerosis in t...

conclusions herpes simplex virus was present in more patients with ms than healthy cases. hsv may be directly or indirectly associated with ms development. further comprehensive molecular studies are needed to confirm the etiopathologic association between hsv and ms disease. results totally, 63 (76.8%) patients with ms showed a history of hsv exposure by anti-hsv testing compared to 70 (78.7%)...

conclusions the prevalence of ms showed an increasing rate of the disease in recent years. decreasing of the female to male ratio and patients’ low socio-economic level, need more studies. the increasing rate of patients with progressive relapsing feature and more disabled patients belong to this subtype show the poor prognosis. results a total of 142 patients were participated in this study. p...

conclusions the findings suggested that according to the ecological conditions of ahvaz, a family history of ms may increase the risk of developing ms. results in both cases and controls, no significant associations were found between arab ethnicity and incidence of ms, marital status and risk of ms in ahvaz, or more than 15-year residency in ahvaz, birth in khuzestan, and month of birth and th...