background: the aim of this preliminary study was to assess the safety and efficacy of high-dose oral vitamin d3 supplementation during pregnancy in women with multiple sclerosis (ms) in isfahan, iran. methods: in a single center open-label randomized, controlled clinical phase i/ii pilot study, 15 pregnant women with confirmed ms with low serum 25-hydroxyvitamin d (25(oh)d) levels were randoml...

background: available evidence shows that tetracycline family has cellular and molecular mechanisms to protect neurons and oligodendrocytes by modulating matrix metalloproteinases. we tried to compare the effectiveness of intramuscular and subcutaneous interferon beta-1a (inf-β1a) in combination with oral doxycycline among patient with relapsing remitting multiple sclerosis (rrms) and secondary...

conclusion statistical analysis of susceptibilities of ms patients versus healthy subjects found no excess deposition of calcium content in deep gray matter of ms patients. calcification may not be considered as a biomarker of prognosis in ms. results magnetic susceptibility(x) of calcium content was assessed by number of pixels induced by gp and put in ms patients as well as healthy subjects. ...

normal 0 false false false en-us x-none ar-sa background: the relation between vitamin d deficiency with depressive and fatigue symptoms in both multiple sclerosis (ms) patients and healthy population have been reported. to represent our regional achievement in this field we investigated the relation between vitamin d status with fatigue and depressive symptoms in ms patients. materials and met...

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background: multiple sclerosis (ms) is an autoimmune disease of central nerves system, in which neurological disabilities occur in young adults. despite increasing number of studies on ms, some aspects of this disorder are still unclear. in the previous studies, it has been proven that there is direct relation between ms incidence and vitamin d deficiency. thereby, strong evidence in ms pathoge...

the inflammatory bowel diseases (ibd) have been found to accompany some neurological syndromes including multiple sclerosis (ms). recently, several studies have reported and discussed the simultaneous presence of ibd and ms in some patients. thus, in patients with either disease, the presence of signs and symptoms of the other should raise the clinical suspicion of the clinician and warrant spe...

background: tehran is the capital of iran with an increasing multiple sclerosis (ms) incidence. a retrospective population-based study was conducted to evaluate the status of ms prevalence and ms incidence trends in tehran province, iran. methods: a population-based study was conducted from 1991 to 2014 in tehran province, the capital city of iran based on iranian ms society (imss) registry sys...

multiple sclerosis is a severe disorder of the central nervous system. this chronic and progressive disease involves unpredictable episodes of inflammatory attacks. it can cause functional limitations, disability and reduced quality of life. pain is a common and significant problem in lots of people with multiple sclerosis (ms). and it is inversely correlated with aspects of life quality in ind...

multiple sclerosis (ms) is a complex disease which is correlated with increasing inflammatory factors, demyelination and axonal loss. in this auto-immune disease, neuroinflammation is mediated by different types of t cells with macrophage/microglial activation and b cells involvement that interact in a collaborative manner. focal inflammation is the main cause for the onset of relapses and coul...