Ecotoxicity testing is a crucial component of chemical risk assessment. Still, due to methodological difficulties related to controlling exposure concentrations over time, data on long-term effects of organic chemicals at low concentrations are limited. The aim of the present study was, therefore, to test the applicability of passive dosing to maintain stable concentrations of the organochlorin...

Contamination of the aquatic environment by EDCs has received considerable attention from scientists, government officials, and the public. E2, one of the EDCs with high estrogenic effect, has the potential to cause multiple endocrine-disrupting effects, even at small concentrations. In the present review, the toxicity of E2 to aquatic organisms was reviewed. Results of published studies show t...

Drought is a major threat to wheat production worldwide and development of drought-tolerant genotypes may improve the this cereal crop in drought affected regions. In present study, 24 mutant lines were developed by treating variety 'NN-Gandum-1(NN-1) with ethyl methane sulfonate (EMS). The M5, M6, M7 generations evaluated for quantitative traits under well irrigated rainfed conditions. Further...

BACKGROUND Coagulation allelic variants associated with venous thromboembolism (VTE) have been suggested to be involved in the pathogenesis of ischemic stroke. This nationwide study aimed at determining whether VTE shares familial susceptibility with ischemic stroke. METHOD AND RESULTS The Swedish Multigeneration Register of 0- to 75-year-old subjects was linked to the Swedish Hospital Discha...

Focal segmental glomerulosclerosis (FSGS) and Alport syndrome (AS) are two major causes of end-stage renal disease (ESRD). A few families with autosomal dominant FSGS have been reported with linkage to chromosome 19q13 or 11q22, while AS is usually linked to mutations in type IV collagen (COL4) subunit genes. A phenotype resembling AS may also be seen with myosin heavy chain-9 (MYH9) gene mutat...

IMPORTANCE Advancing paternal age has been linked to autism. OBJECTIVE To further expand knowledge about the association between paternal age and autism by studying the effect of grandfathers' age on childhood autism. DESIGN Population-based, multigenerational, case-control study. SETTING Nationwide multigeneration and patient registers in Sweden. PARTICIPANTS We conducted a study of in...

BACKGROUND The subject of epigenetic risk of assisted reproduction treatment (ART), initiated by reports on an increase of children with the Beckwith-Wiedemann imprinting disorder, is very topical. Hence, there is a growing literature, including mouse studies. METHODS In order to gain information on transgenerational epigenetic inheritance and epigenetic effects induced by ART, literature dat...

The long-term fitness of individuals is examined in complex and temporally dynamic ecosystems. We call this multigeneration fitness measure "future fitness". Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) is a polyphagous insect that feeds on many wild and cultivated hosts. While four generations of H. zea occur during the cropping season in the U.S. Mid Southern agroecosysem, the latter two...

Background—This nationwide study sought to determine ageand gender-specific familial risks in siblings hospitalized for venous thromboembolism (VTE). Methods and Results—The Swedish Multigeneration Register on 0to 75-year-old subjects was linked to the Hospital Discharge Register for the years 1987–2007. Standardized incidence ratios were calculated for individuals whose siblings were hospitali...