background: resistance to anti-tuberculosis (tb) drugs is a global problem. previous studies showed that the prevalence of primary mdr-tb is higher and has been increasing. the purpose of this study was to determine the primary drug resistance in strains isolated from patients with smear-positive of the new cases to anti-tb drugs. methods: in this cross-sectional study, 266 smear positive pulmo...

Multidrug-resistant pathogens are an emerging global health problem. In addition to the need of developing new antibiotics in the pipeline, the ability to rapidly determine the antibiotic resistance profiles of bacteria represents one of the most crucial steps toward the management of infectious diseases and the prevention of multidrug-resistant pathogens. Here, we report a single cell antimicr...

Enterococci are Gram-positive facultative anaerobic bacteria commonly found in the gastrointestinal tract of the mammals and birds. These cocci are isolated from urinary tract infections, bacteremia, endocarditis, and burn wounds in humans. The evolution of antibiotic-resistant enterococci raised a problem due to the possibility of the transmission of these organisms between poultry and human. ...

Objective: Incidence of ventilator-associated pneumonia, caused by gram-negative multidrug resistant bacteria, is on the increase and early mortality rate high.
 We aimed to investigate effects aging, comorbidities, high Charlson comobidity index score, Acute Physiology Chronic Health Evaluation II leukocytosis, C-reactive protein level, inappropriate empirical antibiotic therapy resistanc...

Antimicrobial resistance (AMR) is a global public health threat, especially for low and middle-income countries (LMIC) where the threat has not been fully identified. Our study aims to describe E. coli AMR in rural communities expand our knowledge on bacterial contamination. Specifically, we aim identify potential dissemination routes of AMR-carrying bacteria humans (children’s stools), communi...

The infectious diseases caused by multidrug-resistant bacteria pose serious threats to humankind. It has been suggested that an antibiotic targeting LpxC of the lipid A biosynthetic pathway in Gram-negative bacteria is a promising strategy for curing Gram-negative bacterial infections. However, experimental proof of this concept is lacking. Here, we describe our discovery and characterization o...

UNLABELLED Marine bacteria are a rich source of bioactive metabolites. However, the microbial diversity of marine ecosystem still needs to be explored. The aim of this study was to isolate and characterize bacteria with antimicrobial activities from various marine coastal environment of New Caledonia. We obtained 493 marine isolates from various environments and samples of which 63 (12.8%) pres...

INTRODUCTION Several guidelines recommend initial empirical treatment with two antibiotics instead of one to decrease mortality in community-acquired pneumonia (CAP) requiring intensive-care-unit (ICU) admission. We compared the impact on 60-day mortality of using one or two antibiotics. We also compared the rates of nosocomial pneumonia and multidrug-resistant bacteria. METHODS This is an ob...

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Editorial In recent years, the sudden increase in the prevalence of an-timicrobial-resistant bacteria and the emergence of multi-drug-resistant bacteria have become serious worldwide problems. Therefore, in 2000, the World Health Organization (WHO) declared ...