Introduction Total hip arthroplasty (THA) is widely successful for the treatment of end-stage hip disease. It significantly improves the quality of a patient’s life by reducing both pain and functional limitation. Many studies have demonstrated excellent survivorship following THA. However, bone resorption, or osteolysis, has emerged as a major concern regarding long-term THA survival. The inci...

ment for colonization and growth of metastatic tumors, and some of the most common human malignancies, notably breast cancer and prostate cancer, have a strong propensity to produce skeletal metastases (1). Tumor cells, in turn, can produce a spectrum of skeletal manifestations which spans diffuse osteopenia, focal osteolysis, focal osteogenesis, and osteomalacia (2). The most common skeletal m...

Ultra-high-molecular weight polyethylene (UHMWPE) wear, debris-induced osteolysis is a frequent cause of failure of total hip arthroplasty. Metal-on-metal total hip arthroplasty eliminates the generation of UHMWPE particulate debris. Although the volumetric wear of a metal-on-metal articulation may be lower than a metal-UHMWPE articulation, the number of particles may be higher. Osteolysis can ...

Introduction: It has been reported recently that urine concentrations of cross-linked N-telopeptides of type I collagen (NTX), a marker of bone resorption, may be elevated in total hip replacement patients with radiographic evidence of periprosthetic osteolysis (1). However, it remains unclear whether bone markers possess the sensitivity to detect early, non-radiographic osteolysis. In the pres...

Total joint replacement, although considered an excellent surgical procedure, can be complicated by osteolysis induced by implant particles and subsequent aseptic loosening of the implant. The pathogenesis of implant-associated osteolysis includes inflammatory and osteolytic processes. The sustained chronic inflammatory response initiated by particulate debris at the implant-bone interface is m...

Total joint replacement, although considered an excellent surgical procedure, can be complicated by osteolysis induced by implant particles and subsequent aseptic loosening of the implant. The pathogenesis of implant-associated osteolysis includes inflammatory and osteolytic processes. The sustained chronic inflammatory response initiated by particulate debris at the implant-bone interface is m...