Multi-trait multi-environment (MTME) models were fitted to eucalyptus breeding trials data assess residual variance structure, genetic stability and adaptability. To do so, 215 clones evaluated in a randomized complete block design with 30 replicates one plant per plot four environments. At 36 months of age, tree diameter at breast height (DBH) pilodyn penetration (PP) measured. Two MTME fitted...

Meta-analysis of multi-arm trials has been used increasingly in recent years. The aim of meta-analysis for multi-arm trials is to combine evidence from all possible similar studies. In this paper we propose normal approximation models by using empirical logistic transform to compare different treatments in multi-arm trials, allowing studies of both direct and indirect comparisons. Additionally,...

Economic evaluation in the form of cost-effectiveness analysis has become a popular means to inform decisions in healthcare. With multi-regional clinical trials in a global development program becoming a new venue for drug efficacy testing in recent decades, questions in methods for cost-effectiveness analysis in the multi-regional clinical trials setting also emerge. This paper addresses some ...

Multi-arm multi-stage designs can improve the efficiency of the drug-development process by evaluating multiple experimental arms against a common control within one trial. This reduces the number of patients required compared to a series of trials testing each experimental arm separately against control. By allowing for multiple stages experimental treatments can be eliminated early from the s...

In early stages of drug development there is often uncertainty about the most promising among a set of different treatments. In order to ensure the best use of resources it is important to decide which, if any, of the treatments should be taken forward for further testing. Multi-arm multi-stage (MAMS) trials provide gains in efficiency over separate randomised trials of each treatment. They all...

A major challenge in the development of anticancer therapies is the considerable time and resources needed for conducting randomized clinical trials (RCT). There is a need for more efficient RCT designs that accelerate development, minimize costs, and make trials more appealing to patients. We review the statistical and logistical characteristics of multi-arm designs that compare several experi...

Adaptive designs that are based on group-sequential approaches have the benefit of being efficient as stopping boundaries can be found that lead to good operating characteristics with test decisions based solely on sufficient statistics. The drawback of these so called “pre-planned adaptive” designs is that unexpected design changes are not possible without impacting the error rates. “Flexible ...

The faba bean (Vicia faba) is a temperate grain legume, that regaining interest due to the high demand for food and feed uses environmental services provided. parasitic weed broomrape (Orobanche crenata) appears as major constraint agricultural production in Mediterranean Basin. yield stability can be managed by adjusting agronomic practices breeding adaptation. In this study, we compared perfo...