Diabetes is considered one of the main threats to global public health in this era. It is increasing rapidly in every part of the world; the prevalence of the disease will grow to the point where 366 million people will be affected by 2030. The prevalence of diabetes mellitus (DM) in the Saudi population is high, and the majority of patients suffer from type 2 DM. Marketed oral antidiabetic dru...

The purpose of this research was to formulate and systemically evaluate in vitro and in vivo performances of mucoadhesive amoxicillin microspheres for the potential use in the treatment of gastric and duodenal ulcers, which were associated with Helicobacter pylori. Amoxicillin mucoadhesive microspheres containing carbopol-934P as mucoadhesive polymer and ethyl cellulose as carrier polymer were ...

Nanoemulsions are alternative means of incorporating functional components into systems. This research aims to model the effect African catfish mucilage (ACM) concentrations on particle size (PS) stable oil-in-water (O/W) nanoemulsions formulated by ultrasonication. A D-optimal mixture design was used study influence three (MCs) ACM, oil, and water PS. Morphology PS were determined with Cryo-TE...

The drive of this exploration is to investigate the mucoadhesive assets A. indica (Azadirachta indica) fruit mucilage by incorporating it into microspheres with Acyclovir (AVR) as a model drug. study was performed check impact proportion on particle size and swelling index. Nine batches AVR were made varying proportions Polyacrylic acid 934P (AIFM). A central composite design expert software de...

The purpose of this research was to formulate and systemically evaluate in-vitro and in-vivo performances of mucoadhesive propranolol hydrochloride microspheres for its potential use in the treatment of hypertension, myocardial infraction and cardiac arrhythmias. Propranolol hydrochloride mucoadhesive microspheres, containing carbopol-934P as mucoadhesive polymer and ethyl cellulose as carrier ...

The mucoadhesive capacity of poly(2-hydroxyethyl methacrylate) (PHEMA) microspheres was studied in contact with Sprague-Dawley rat jejunum at pH = 6 and at 22°C. Dry PHEMA microparticles exhibited adequate mucoadhesive capacity, which was independent of nominal crosslinking ratio. When PHEMA microparticles were loaded with linear PEO chains of molecular weight 1000, the mucoadhesive capacity in...

The present study deals with the formulation and of oromucosal tablets Rizatriptan Benzoate (RB) using different bioahdesive polymer. Nine formulations were prepared by direct compression method. Hydroxypropyl methyl cellulose (HPMC K4M), Gum acacia Sodium Alginate used as buccal mucoadhesive Ethyl (EC) an impermeable backing layer. FTIR Studies showed no interaction drug, polymer excipients. 3...

Abstract: Objectives: The intention of present study is to formulate and optimize the famotidine mucoadhesive tablets y using Central Composite Design. Materials Methods: concentrations Cordia dichotoma fruit mucilage powder (X1) Polyvinyl pyrrolidone (X2) were demonstrated as independent variables. Whereas, dependent variables selected such an in vitro Mucoadhesion Time percentage Drug Release...

This study describes the effect of Guar gum and chitosan on formulation of mucoadhesive drug delivery system of itraconazole. Mucoadhesive strength, Drug content, Hardness, Friability, Weight variation, Moisture content and accelerated stability studies were performed to study the effect of polymers on prepared mucoadhesive tablets. Results of the present study clarified the potential of guar g...