نتایج جستجو برای: mucin

تعداد نتایج: 10038  

Journal: :Glycobiology 1997
P A Nielsen E P Bennett H H Wandall M H Therkildsen J Hannibal H Clausen

Human saliva contains high and low molecular weight mucin glycoproteins, that are distinct. Recently the gene encoding low molecular weight salivary mucin was cloned and designated MUC7, whereas the primary structure of high molecular weight salivary mucin is unclear. Furthermore, the expression patterns of high and low molecular weight salivary mucins in salivary glands have been debated. We h...

Journal: :Annals of oncology : official journal of the European Society for Medical Oncology 1999
Y S Kim J R Gum S C Crawley G Deng J J Ho

Mucins are high molecular weight glycoproteins which are heavily glycosylated with many carbohydrate side chains. In epithelial cancers such as biliopancreatic cancer, both quantitative and qualitative alterations in carbohydrate and polypeptide moieties of mucin glycoproteins occur. These changes in mucin glycoproteins are one of the most common phenotypic markers of biliopancreatic carcinogen...

Journal: :Cancer research 1990
M S Lan M A Hollingsworth R S Metzgar

This work describes the molecular properties of the polypeptide core of a human pancreatic mucin antigen isolated from a human pancreatic adenocarcinoma cell line, HPAF. Pancreatic tumor mucin was isolated by a combination of molecular sieve chromatography and CsCl/4 M guanidine-HCl density gradient ultracentrifugation. Trifluoromethane sulfonic acid was used to remove carbohydrate units from p...

Journal: :Cancer research 1993
R Dahiya K S Kwak J C Byrd S Ho W H Yoon Y S Kim

Previous studies have suggested that mucin gene expression is tissue-specific; however, the relationship between unique mucin gene products and the biochemical properties of mucins is unknown. The purpose of this study was to determine the biochemical and molecular characteristics of mucin synthesized by adenocarcinoma cell lines derived from breast (ZR-75-1), stomach (MGC-803), pancreas (Capan...

Journal: :Sensors and Actuators B-chemical 2021

Abstract Mucin-1 (MUC-1) is associated with a broad range of human epithelia including gastric, lung and colorectal. In this work, direct competitive electrochemical immunosensor based on gelatin modified transduction platform was designed. Dopamine (DA)/mucin-1 functionalized electro-active carbon nanotubes were employed as signal generating probes in the construction for early stage diagnosis...

Journal: :European Journal of Inflammation 2021

Objectives Mucin phenotype is a tool to classify gastric cancer, but the relationship between mucin and its malignancy still controversial. This study aimed clarify malignant potential of cancer. Methods A total 82 cases early-stage differentiated adenocarcinoma (submucosal invasion cases) obtained from surgeries were studied by immunohistochemistry. Gastric E-cadherin expression analyzed in mu...

Journal: :Gastroenterology 1982

2013
Niklas Muenchmeier Sophia Boecker Lorenz Bankel Laura Hinz Nicole Rieth Constantin Lapa Anna N. Mendler Elfriede Noessner Ralph Mocikat Peter J. Nelson

BACKGROUND Cellular therapy is a promising therapeutic strategy for malignant diseases. The efficacy of this therapy can be limited by poor infiltration of the tumor by immune effector cells. In particular, NK cell infiltration is often reduced relative to T cells. A novel class of fusion proteins was designed to enhance the recruitment of specific leukocyte subsets based on their expression of...

Journal: :Cancer research 1994
Y Kotera J D Fontenot G Pecher R S Metzgar O J Finn

Using synthetic peptides 60,80, and 105 residues long, corresponding to 3, 4, and 5.25 tandem repeats of human mucin MUC-1 protein core, as antigens in a solid-phase enzyme-linked immunosorbent assay, we screened sera from 24 breast cancer patients, 10 colon cancer patients, and 12 pancreatic cancer patients, at various stages of disease, for the presence of mucin-specific antibodies. The 105-r...

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