Objective and Importance: Internal Carotid Artery (ICA) stenosis is a common condition with a high prevalence in the normal population and carries a high risk of stroke. Hemodynamic impairment has been proven to be a powerful and independent risk factor for stroke. Understanding the hemodynamics beyond a stenosis may play a role in selecting patients who would benefit from treatment, determinin...

Invasion through the extracellular matrix (ECM) is important for wound healing, immunological responses and metastasis. We established an invasion-based cell motility screen using Boyden chambers overlaid with Matrigel to select for pro-invasive genes. By this method we identified antisense to MARCKS related protein (MRP), whose family member MARCKS is a target of miR-21, a microRNA involved in...

To evaluate the clinically important mechanisms of drug resistance in breast cancer, the expression of the MRP gene and the corresponding one for the MDR1 gene were determined in primary breast carcinoma specimens by both reverse transcription-PCR (n = 134) and immunohistochemistry (n = 63). Expression of MRP RNA was observed in all breast cancer specimens. MDR1 RNA was detected in 80 (60%) of ...

RNase mitochondrial RNA processing (RNase MRP) mutants have been shown to have an exit-from-mitosis defect that is caused by an increase in CLB2 mRNA levels, leading to increased Clb2p (B-cyclin) levels and a resulting late anaphase delay. Here we describe the molecular defect behind this delay. CLB2 mRNA normally disappears rapidly as cells complete mitosis, but the level remains high in RNase...

Mitogen-regulated protein (MRP) is secreted by certain immortal murine cell lines (Swiss 3T3, BNL) stimulated with serum or particular growth factors. We have identified a cDNA clone that encodes part of the protein and have confirmed that MRP is closely related to, if not identical to, the prolactin-related protein designated proliferin. MRP is not produced by primary mouse embryo fibroblasts ...

A total of 323 isolates of Streptococcus suis recovered from diseased or healthy pigs in France were serotyped. The presence of virulence-related proteins, Muraminidase-Released Protein (MRP), Extracellular Factor (EF) and Suilysin was also studied in 122 isolates of capsular types 2, 1/2, 9, 7 and 3 to evaluate their implication in virulence of S. suis. Capsular types 2, 1/2, 9, 7 and 3 were t...

Institute of Neuroscience and Medicine-4, Forschungszentrum Juelich, Germany Dynamic PET provides temporal information about tracer uptake. However, each PET frame has usually low statistics, resulting in noisy images. The goal is to study effects of prior regularisation on dynamic PET data. Quantification and noise in imagedomain and time-domain as well as impact on parametric images is assess...

proteins as P-gp (6, 7)•4 Like P-gp, transfection of drug-sensitive cells with a full-length MRP cDNA is sufficient to confer multidrug re sistance (7).5 However, despite the fact that both P-gp and MRP confer resistance to a similar spectrum of anticancer drugs, these two proteins share less than 15% amino acid identity (6). MAbs against P-gp have played a critical role in determining the re...

The aim of this study was to determine the dual effect of Maillard reaction and fermentation on the preventive cardiovascular effects of milk proteins. Maillard reaction products (MRP) were prepared from the reaction between milk proteins, such as whey protein concentrates (WPC) and sodium caseinate (SC), and lactose. The hydrolysates of MRP were obtained from fermentation by lactic acid bacter...

This study reports novel modified rice protein (MRP)-ammonium shellac (NH4SL) enteric composite coatings on millimeter-sized probiotics pellets to protect the survival of during storage, thermal treatments, and simulated gastrointestinal (GI) digestions. An aqueous MRP solution at pH 7.0–13.0 was dropwise added into an ethanol NH4SL 8.2, mixture significantly affected homogeneity MRP-NH4SL susp...