objective: orexin is a hypothalamic orexigenic neuropeptide, which third cerebral injection of it mainly exerts inhibitory effects on reproductive functions. it increases significantly the aromatase (cyp19) gene expression in the hypothalamus of male rats. aromatase is an enzyme which converts androgens to estradiol in the hypothalamus of rats. prenatal or neonatal exposure of females to testos...

background helicobacter pylori infection is associated with gastritis and marked infiltration of the gastric mucosa by several cytokines secreting inflammatory cells that contribute to sustained local inflammation. in this study, we sought to examine il-6 expression in h. pylori-infected and uninfected gastric mucosa and elucidate the implication in the pathogenesis of h. pylori-associated gast...

Background Neoplastic adenomatous polyps generating from the epithelial cells are considered benign tumors. Adenomatous polyps are common in western countries and it can take seven to 10 or more years for an adenoma to evolve into cancer.  The Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway, is a signaling pathway that controls organ size in animals through the r...

interest in hydroxy - carboxylic acid 2 (hca2) receptor has been raised since it is the target of antidyslipidemic drug nicotinic acid. the present study aimed to evaluate the presence of mrna of this receptor in different organs of laboratory rat. twenty two different organs of rats including mesenteric fat, epididymis (head, body and tail), testis, ovary, xiphoid process, liver, adrenal gland...

runx3, a member of runt-related transcription factor (runx) proteins with tumor suppressor effect, is a tissue–restricted and cancer related transcription factor that regulate cell proliferation and growth, as well as differentiation. in the present study, exogenous run3 was transiently expressed in ags (human gastric adenocarcinoma), with undetectable runx3 protein and in a549 (human lung carc...

I briefly review the source of the so-called intrinsic ambiguity and show how the combination of “golden” and “silver” channel at the Neutrino Factory can solve the problem, in the absence of other sources of degeneracies. I then relaxed the hypothesis θ23 = 45◦ and show how the different dependence of the two channels on θ23 can help in solving the intrinsic and θ23-octant ambiguity at the sam...

Introduction: The aim of the study was to investigate the structural and hemodynamic changes as well as cardiac transcriptional profile of the key regulatory proteins, sirtuins family (SIRT1-7), in adaptive and mal-adaptive phases of left ventricular hypertrophy (LVH). Methods: LVH was induced in male Wistar rats (190±20g) by abdominal aortic banding. The third and sixteenth weeks post-surgery ...