نتایج جستجو برای: mri contrast agents

تعداد نتایج: 820278  

2017
Francisco Perez-Balderas Sander I van Kasteren Alaa A A Aljabali Kim Wals Sébastien Serres Andrew Jefferson Manuel Sarmiento Soto Alexandre A Khrapitchev James R Larkin Claire Bristow Seung Seo Lee Guillaume Bort Filippo De Simone Sandra J Campbell Robin P Choudhury Daniel C Anthony Nicola R Sibson Benjamin G Davis

Ligand-conjugated microparticles of iron oxide (MPIO) have the potential to provide high sensitivity contrast for molecular magnetic resonance imaging (MRI). However, the accumulation and persistence of non-biodegradable micron-sized particles in liver and spleen precludes their clinical use and limits the translational potential of MPIO-based contrast agents. Here we show that ligand-targeted ...

Journal: :international journal of bio-inorganic hybrid nanomaterials 0

magnetic nanoparticles are the good choice for using in mri as the contrast agent. iron oxide particles such as magnetite (fe3o4) or its oxidized form maghemite (γ-fe2o3) are the most commonly employed in biomedical applications. in this study, we synthesized and optimized the preparation of chitosan manganese-ferrite nanoparticles (cmn-fe nps) and evaluated its ability for the mice macrophage ...

Journal: :Frontiers in bioscience : a journal and virtual library 2008
Byunghee Yoo Mark D Pagel

This review focuses on MR contrast agents that are responsive to a change in physiological environment. The "response" mechanisms are dependent on 6 physicochemical phenomena, including the accessibility of water to the agent, rotational tumbling time, proton exchange rate, electron spin state, MR frequency, or local field inhomogenieties caused by the agent. These phenomena can be affected by ...

2008
M. Oostendorp K. Douma T. M. Hackeng M. A. van Zandvoort M. J. Post W. H. Backes

Introduction Molecular MRI allows the specific detection of biomolecules that are upregulated during disease. To this extent, contrast agents (CAs) are used that home to the targeted biomolecules via high affinity ligands coupled to the CA. Activated endothelial cells in tumor angiogenesis provide well suited disease markers, which are easily accessible for circulating CAs. Several studies have...

2016
Rajneesh Chaudhary Kislay Roy Rupinder Kaur Kanwar Ken Walder Jagat Rakesh Kanwar

BACKGROUND Cardiovascular diseases are the most prevalent cause of morbidity and mortality affecting millions of people globally. The most effective way to counter cardiovascular complications is early diagnosis and the safest non-invasive diagnostic approach is magnetic resonance imaging (MRI). In this study, superparamagnetic ferrite nanoparticles doped with zinc, exhibiting highly enhanced s...

2009
Ilgar Mamedov Goran Angelovski Jörg Henig Éva Tóth Nikos K. Logothetis Hermann A. Mayer

MRI Contrast Agents Ilgar Mamedov, Goran Angelovski, Jörg Henig, Éva Tóth, Nikos K. Logothetis and Hermann A. Mayer Department for Physiology of Cognitive Processes, Max-Planck Institute for Biological Cybernetics, Tübingen, Germany, Institute for Inorganic Chemistry, University of Tübingen,Tübingen, Germany, 3 Centre de Biophysique Moléculaire CNRS rue Charles Sadron, 45071 Orléans, Cedex 2, F...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2017
He Wei Oliver T Bruns Michael G Kaul Eric C Hansen Mariya Barch Agata Wiśniowska Ou Chen Yue Chen Nan Li Satoshi Okada Jose M Cordero Markus Heine Christian T Farrar Daniel M Montana Gerhard Adam Harald Ittrich Alan Jasanoff Peter Nielsen Moungi G Bawendi

Medical imaging is routine in the diagnosis and staging of a wide range of medical conditions. In particular, magnetic resonance imaging (MRI) is critical for visualizing soft tissue and organs, with over 60 million MRI procedures performed each year worldwide. About one-third of these procedures are contrast-enhanced MRI, and gadolinium-based contrast agents (GBCAs) are the mainstream MRI cont...

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