نتایج جستجو برای: mps

تعداد نتایج: 4974  

2015
Sounik Sarkar Anjan Kr Dasgupta

Microparticles (MPs) have great potentiality in material science- based applications. Their use in biology is however limited to clinics and has rarely been exploited in the pharmaceutical context. Unlike nanoparticles (NPs), they are amenable to routine detection by flow cytometry and confocal microscopy. Though MPs can constitute a wide variety of materials, including ceramics, glass, polymer...

Journal: :Journal of controlled release : official journal of the Controlled Release Society 2010
Hilliard L Kutscher Piyun Chao Manjeet Deshmukh Yashveer Singh Peidi Hu Laurie B Joseph David C Reimer Stanley Stein Debra L Laskin Patrick J Sinko

The relationship between microparticle (MP) size and lung targeting efficiency, intra-lung distribution and retention time was systematically studied after intravenous administration of rigid fluorescent polystyrene MPs of various sizes (2, 3, 6 and 10 microm) to Sprague Dawley rats. Total fluorescence was assessed and it was found that 2 microm and 3 microm MPs readily passed through the lung ...

2017
Allison L. Teunis Taissia G. Popova Virginia Espina Lance A. Liotta Serguei G. Popov

We recently reported that the open-mesh (0.7 μ) polyacrylamide microparticles (MPs) with internally-coupled Cibacron affinity dye demonstrate protective effect in mice challenged into footpads with high doses (200 LD50) of anthrax (Sterne) spores. A single injection of MPs before spore challenge reduces inflammatory response, delays onset of mortality and promotes survival. In this study, we sh...

2017
Chin-Chou Wang Chia-Cheng Tseng Huang-Chih Chang Kuo-Tung Huang Wen-Feng Fang Yu-Mu Chen Cheng-Ta Yang Chang-Chun Hsiao Meng-Chih Lin Chi-Kung Ho Hon-Kan Yip

We investigated whether circulating microparticles (MPs) could serve as prognostic biomarkers in non-small cell lung cancer (NSCLC) patients. We enrolled 25 control subjects and 136 NSCLC patients categorized into disease-progression (DP, n=42) and disease-control (DC, n=94) groups. Flow cytometric analysis showed that levels of four types of circulating microparticles (EDAc-MPs, EDAp-MPs, PDAc...

Journal: :International heart journal 2012
Ravindra Bhardwaj Harvinder Dod Mitchell S Finkel Imran Dar Gerald R Hobbs Alan M Ducatman Bradford Warden Wissam Gharib Robert J Beto Abnash C Jain

A stress-induced myocardial perfusion abnormality (MPS), in the absence of angiographically significant epicardial coronary artery disease, is considered a "false-positive" test result. We hypothesized that echocardiography would provide complementary prognostic and pathophysiologic data relevant to the management of patients with MPS and normal coronary angiograms. Accordingly, left atrial vol...

2014
Katherine D. Connolly Gareth R. Willis Dev B. N. Datta Elizabeth A. Ellins Kristin Ladell David A. Price Irina A. Guschina D. Aled Rees Philip E. James

Lipoprotein-apheresis (apheresis) removes LDL-cholesterol in patients with severe dyslipidemia. However, reduction is transient, indicating that the long-term cardiovascular benefits of apheresis may not solely be due to LDL removal. Microparticles (MPs) are submicron vesicles released from the plasma membrane of cells. MPs, particularly platelet-derived MPs, are increasingly being linked to th...

Journal: :The Journal of the Association of Physicians of India 2013
Shashwat Verma I Sathyamurthy S Shelley M Indirani Alok S Pawaskar K Jayanthi P Ramachandran

OBJECTIVE To identify coronary artery disease (CAD) in asymptomatic diabetics with the help of myocardial perfusion single photon emission computed tomography (MPS), a non-invasive imaging modality and its correlation in diabetics with or without microalbuminuria. METHODS This study included 99 patients in the age group of 30 to 80 years who were asymptomatic but possessed one or more risk fa...

Journal: :Cell 2007
Carl R. Walkley Gemma Haines Olsen Sebastian Dworkin Stewart A. Fabb Jeremy Swann Grant A. McArthur Susan V. Westmoreland Pierre Chambon David T. Scadden Louise E. Purton

Myeloproliferative syndromes (MPS) are a heterogeneous subclass of nonlymphoid hematopoietic neoplasms which are considered to be intrinsic to hematopoietic cells. The causes of MPS are largely unknown. Here, we demonstrate that mice deficient for retinoic acid receptor gamma (RARgamma), develop MPS induced solely by the RARgamma-deficient microenvironment. RARgamma(-/-) mice had significantly ...

2017
Brian Young Jonathan L King Bruce Budowle Luigi Armogida

Amplicon (targeted) sequencing by massively parallel sequencing (PCR-MPS) is a potential method for use in forensic DNA analyses. In this application, PCR-MPS may supplement or replace other instrumental analysis methods such as capillary electrophoresis and Sanger sequencing for STR and mitochondrial DNA typing, respectively. PCR-MPS also may enable the expansion of forensic DNA analysis metho...

2010
Elan D. Louis Gertrude H. Sergievsky

Background—Mild Parkinsonian signs (MPS) are a marker for incident dementia. MPS have been linked with cerebrovascular disease, which can be evaluated using magnetic resonance imaging (MRI). Also, if MPS are a marker for developing Alzheimer's type changes, hippocampal volume on MRI might be diminished among individuals with MPS. Objective—To examine white matter hyperintensity (WMH) volume and...

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