Mutation of the inositol 5-phosphatase OCRL1 causes Lowe syndrome and Dent-2 disease. Loss of OCRL1 function perturbs several cellular processes, including membrane traffic, but the underlying mechanisms remain poorly defined. Here we show that OCRL1 is part of the membrane-trafficking machinery operating at the trans-Golgi network (TGN)/endosome interface. OCRL1 interacts via IPIP27A with the ...

Multipoint relays ”MPR” have been introduced in the proactive protocol OLSR in order to optimize the flooding overhead of control traffic. In this paper we propose a protocol NFCF to optimize the Network Coding based flooding using Fountain Codes such as LT code. our protocol combine the MPR technique with the notion of network coding where MPR nodes do not simply forward packets they overhear ...

A theory of double magnetophonon resonance (MPR) in quantum wells in magnetic field is developed. The magnetic field is assumed to be tilted at an angle θ to the perpendicular to the plane of quantum well. The resonance is due to the resonant interaction of 2D conduction electrons with the longitudinal optic phonons. The electrons are assumed to be nondegenerate. The θ-dependence of MPR maxima ...

BACKGROUND This study examined the relationship of medication adherence to frequency of pulmonary exacerbation and rate of decline in FEV(1)% predicted (FEV(1)). METHODS 95 CF patients aged 6 years or older and prescribed a pulmonary medication, were enrolled in a longitudinal retrospective review of medication adherence and health outcomes (the occurrence and frequency of intravenous (IV) an...

The serine proteinase granzyme B is crucial for the rapid induction of target cell apoptosis by cytotoxic T cells. Granzyme B was recently demonstrated to enter cells in a perforin-independent manner, thus predicting the existence of a cell surface receptor(s). We now present evidence that this receptor is the cation-independent mannose 6-phosphate/insulin-like growth factor receptor (CI-MPR). ...

With the improvement of the physical layer’s ability to receive multiple packets sent simultaneously, the classical collision channel model no longer applies and a general MPR model should be employed. We investigate the effect of MPR on the CSMA protocol, which previously have not been studied under such model. By analyzing the stability region of CSMA, we find that CSMA’s open-loop throughput...

In this paper, we propose a novel lossless volumetric medical image compression scheme using three-dimensional differential pulse code modulation (3-D DPCM), which provides an efficient procedure to achieve progressive multi-planar reformatting (MPR) of large 3-D medical data sets. Being separable and commutative in the order of its application, 3-D DPCM provides an opportunity to generate MPR ...

The goal of noisy high-dimensional phase retrieval is to estimate an s-sparse parameter β∗ ∈ R from n realizations of the model Y = (X>β∗)2 + ε. Based on this model, we propose a significant semi-parametric generalization called misspecified phase retrieval (MPR), in which Y = f(X>β∗, ε) with unknown f and Cov(Y, (X>β∗)2) > 0. For example, MPR encompasses Y = h(|X>β∗|) + ε with increasing h as ...