Due to the strong development of nanotechnologies, ultrafine particles could represent a growing hazard for workers health. When it is not possible to reduce the risk at its source, filtration systems are one of the means used to limit the exposure to hazardous substances such as airborne particles. The aim of this study is to measure the penetration of nanoparticles on a very large diameter ra...

High temperature requirement protein A1 (HtrA1), a secreted serine protease of the HtrA family, is associated with a multitude of human diseases. However, the exact functions of HtrA1 in these diseases remain poorly understood. We seek to unravel the mechanisms of HtrA1 by elucidating its interactions with chemical or biological modulators. To this end, we screened a small molecule library of 5...

Megakaryocytes (Mgks) are terminally differentiated blood cells specified to produce platelets, whereas hematopoietic stem cells (HSCs) are the most undifferentiated blood cells that retain multipotency to produce all kinds of blood cells. As such, these two cell types reside at the bottom and the top of the hematopoietic hierarchy, respectively. In spite of this distance, they share several im...

Despite major therapeutic advancements, worldwide death rates of acute myeloid leukemia (AML) remain high, with approximately 20,830 people diagnosed in the USA in 2015, 10,460 (50.21%) of whom were estimated to die from the disease. Several studies have shown that leukemia stem cells (LSCs), the founder cells from which AML arise, are characterized by specific transcriptional and epigenetic pr...

The identity of T-cell progenitors that seed the thymus has remained controversial, largely because many studies differ over whether these progenitors retain myeloid potential. Contradictory reports diverge in their use of various in vitro and in vivo assays. To consolidate these discordant findings, we compared the myeloid potential of 2 putative thymus seeding populations, common lymphoid pro...

We present a visualization tool for the monitoring and debugging of codes run in a parallel and distributed computing environment, called Lilith Lights. This tool can be used both for debugging parallel codes as well as for resource management of clusters. It was developed under Lilith, a framework for creating scalable software tools for distributed computing (http : //dancer. ca. sandia. gov/...

UNLABELLED The number of computed tomography examinations has continuously increased over the last decades and accounts for a major part of the collective radiation dose from medical investigations. For purposes of quality assurance in modern radiology a systematic monitoring and analysis of dose related data from radiological examinations is mandatory. Various ways of collecting dose data are ...

Data envelopment analysis (DEA) provides an optimization methodology for deriving an efficiency score for each member of a set of peer decision-making units. Under the original DEA model it was assumed that there is constant returns to scale (CRS). This idea was later extended to the more general case that allowed for variable returns to scale (VRS). In both of these structures, it is assumed t...

O(N) algorithms for N{body simulations enable the simulation of particle systems with up to 100 million particles on current Massively Parallel Processors (MPPs). Our optimization techniques mainly focus on minimizing the data movement through careful management of the data distribution and the data references, both between the memories of diierent nodes, and within the memory hierarchy of each...

Polycomb-group RING finger proteins (Pcgf1-Pcgf6) are components of Polycomb repressive complex 1 (PRC1)-related complexes that catalyze monoubiquitination of histone H2A at lysine 119 (H2AK119ub1), an epigenetic mark associated with repression of genes. Pcgf5 has been characterized as a component of PRC1.5, one of the non-canonical PRC1, consisting of Ring1a/b, Rybp/Yaf2 and Auts2. However, th...