The variable number of tandem repeat polymorphism in the 3'-untranslated region of the dopamine transporter gene (DAT) may influence the variability of the therapeutic response to methylphenidate (MPH) in Attention Deficit/Hyperactivity Disorder (ADHD). For this reason we evaluated the neuropsychological functioning after a prolonged period of MPH treatment and after a specific time from MPH su...

Noradrenergic neurons send widespread projections to sensory networks throughout the brain and regulate sensory processing via norepinephrine (NE) release. As a catecholamine reuptake blocker, methylphenidate (MPH) is likely to interact with noradrenergic transmission and NE modulatory action on sensory systems. To characterize the neurochemical actions of MPH in the primary sensory cortex of f...

BACKGROUND Methylphenidate (MPH) is a psychostimulant that exerts its pharmacological effects via preferential blockade of the dopamine transporter (DAT) and the norepinephrine transporter (NET), resulting in increased monoamine levels in the synapse. Clinically, methylphenidate is prescribed for the symptomatic treatment of ADHD and narcolepsy; although lately, there has been an increased inci...

OBJECTIVE The objective of this study was to evaluate the efficacy and safety of methylphenidate HCL OROS extended-release (OROS-MPH) among children with attention deficit hyperactivity disorder (ADHD) who had been previously treated with methylphenidate HCL immediate-release (MPH-IR). METHODS The sample included 102 children aged 6-12 (9.4±2.6) years who had been diagnosed with ADHD accordin...

Republic of Congo Reena Doshi, MPH; Calixte Shidi, MD; Nicole Hoff, MPH; Jean-Jacques Muyembe, MD, PhD; Emile Okitolonda, MD; Anne Rimoin, PhD, MPH; Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA; Ministry of Health, Expanded Programme on Vaccination, Kinshasa, Congo-Kinshasa; Institut National de Recherché Bio-Medicale, Kinshasa, Congo-Kinshasa; Kinshasa School of Public ...

Multicast communication is one of particular important services in peer-to-peer networking context. The problem of finding a minimum cost multicast routing is NP-completeness. We present a novel solution to improve the MPH algorithm. The cost of multicast tree generated by the proposed algorithm with the same time as MPH is not larger than that of MPH in the worst case.

OBJECTIVE This study was conducted to assess the long-term effect of methylphenidate (MPH) or atomoxetine (ATX) on growth in attention-deficit/hyperactivity disorder (ADHD) drug-naïve children. DESIGN The study was an observational, post-marketing, fourth phase study. METHODS Data on height and weight were collected at baseline and every 6 months up to 24 months. RESULTS Both ATX and MPH ...