An improved temperature-shift selection and screening method is described for the isolation of temperature-sensitive mutants of foot and mouth disease virus.

Antigenic variation of type Asia 1 foot and mouth disease (FMD) virus in Thailand was examined using a total of 50 field viruses isolated between 1986 and 1992. A two-dimensional serum neutralisation test was used to calculate r values for comparison of these isolates with a reference vaccine strain, Asia 1 Bangkok 1960 (BKK/60). Viruses were also compared to two field isolates, Asia 1 36-2/88 ...

Comparison of nucleotide sequences of the partial 1D region of foot-and-mouth disease type C viruses of Indian origin with those of European, South American, and Southeast Asian viruses revealed that the Indian viruses form a distinct genotype. The vaccine strain C IND/51/79 belongs to this genotype and may be a prototype strain of this genotype.

OBJECTIVE To estimate potential spread of foot-and-mouth disease (FMD) if introduced from wild pigs in California and to evaluate efficacies of various control strategies. SAMPLE POPULATION Data for California livestock and from hunter surveys on wild pigs in California. PROCEDURES A spatial, stochastic simulation model was used to simulate FMD epidemics that might occur if a dairy or beef ...

1970年,北 海 道 にHand,foot and mouth disease の 大 き な流 行 の あつ た 際 に,Coxsackie A 16と こ の ウ イル ス 以外 にCoxsackie Aウ イ ル ス が分 離 され た. これ らの うち,帯 広,旭 川,札 幌 の3地 区 の 患者153 名 か ら,サ ル 腎 初 代 培 養 細 胞 に よつ てCoxsackie A 16 が79株(51.6%),未 同定 の ウイ ル ス が25株(16.3%) が分 離 され た. 一 方 ,同 一 被 検 体 を 哺 乳 マ ウス接 種 に よつ て,Coxsackie A 16が61株(39.9%)分 離 され た ほ か に,Coxsackie A4が17株(11.1%),A5が27株(17.6%),A6 が63株(41.2%),A10が9株(5.9%)が 分...

Control and prevention of foot and mouth disease (FMD) by vaccination remains unsatisfactory in endemic countries. Indeed, consistent and new FMD epidemics in previously disease-free countries have precipitated the need for a worldwide control strategy. Outbreaks in vaccinated animals require that a new and safe vaccine be developed against foot and mouth virus (FMDV). FMDV can be eradicated wo...

The complete genome sequences of four foot-and-mouth disease viruses of South African territories 1 (SAT 1) serotype are reported. These viruses originate from an outbreak in Nigeria in 2015 and belong to the novel SAT 1 topotype X from the west and central African virus pool.

Complement-fixation patterns were established for four subtypes of foot-and-mouth disease virus by block assays against homologous and heterologous antiserum. Inhibition of fixation by excess antigen was observed in most homologous systems but rarely in the heterologous systems. The heterologous antibody titers were, in all instances, considerably lower than those for the homologous systems. Al...

BACKGROUND Hand, foot and mouth disease (HFMD) has circulated in China and caused yearly outbreak. To understand the transmission of the disease and to assess the spatial variation in cases reported, we examined age-specific transmission characteristics and reporting rates of HFMD for 31 provinces in mainland China. METHODS We first analyzed incidence spatial patterns and age-specific inciden...

In order to tackle both regional and global foot-and-mouth disease virus (FMDV) epdimics, we hereby develop a rapid microfluidic thermal lens microscopic method to screen swine type O FMDV with good efficiency. The scheme has great merits in terms of field portability, sample volume, assay time, analytical sensitivity, and test reproducibility.