Transcription factors (TFs) recognize and bind to specific DNA sequences. The specificity of a TF is usually represented as a position weight matrix (PWM). Several databases of DNA motifs exist and are used in biological research to address important biological questions. This overview describes PWMs and some of the most commonly used motif databases, as well as a few of their common applications.

We present the solution-state NMR structures and preliminary functional characterizations of three venom peptides identified from the spitting spider Scytodes thoracica. Despite little sequence identity to other venom peptides, structural characterization reveals that these peptides contain an inhibitor cystine knot motif common to many venom peptides. These are the first structures for any pep...

The accumulation of trehalose is a critical determinant of stress resistance in the yeast Saccharomyces cerevisiae. We have constructed a yeast strain in which the activity of the trehalose-hydrolyzing enzyme, acid trehalase (ATH), has been abolished. Loss of ATH activity was accomplished by disrupting the ATH1 gene, which is essential for ATH activity. The delta ath1 strain accumulated greater...

Although it is well established that exercise training conditions the vasculature (Joyner and Green, 2009), the status of arterial function in long-term trained subjects (i.e., athletes, ATH) has been recently disputed (Green, 2013; Montero et al., 2013). The controversy arose as to whether vasodilator function was enhanced in ATH compared with untrained healthy peers (Green et al., 2013). This...

Centromere protein B, which is involved in centromere formation, binds to centromeric repetitive DNA by recognizing a nucleotide motif called the CENP-B box. Humans have large numbers of CENP-B boxes in the centromeric repetitive DNA of their autosomes and X chromosome. The current understanding is that these CENP-B boxes are located at identical positions in the repeat units of centromeric DNA...

The design of new optogenetic tools for controlling protein function would be facilitated by the development of protein scaffolds that undergo large, well-defined structural changes upon exposure to light. Domain swapping, a process in which a structural element of a monomeric protein is replaced by the same element of another copy of the same protein, leads to a well-defined change in protein ...

Résumé. Nous proposons une méthode originale pour extraire un résumé compact, représentatif et intelligible des motifs fréquents dans des données transactionnelles ou séquentielles. Notre approche consiste à extraire un nouveau type de motifs que nous appelons motifs récursifs, i.e. des motifs de motifs, à l’aide d’un algorithme hiérarchique agglomératif nommé RepaMiner. Nous générons non pas u...

ABSTRACT The objective of this research was to create museum texts and educational materials for a textiles section major year-long university exhibit focused on exploring Japanese culture aesthetics through works fine applied art. Little background information about the available. A sample historical kimono, yukata, obi in collection examined using material semiotics methods. motifs present we...

Batik is a traditional art developed in Java. has variety of motifs and it exquisite. One the valuable sources on batik classical batik, which several places Java before Indonesian independence. Besides being picturesque, also values guided by teachings Javanese culture are contained its motifs. Then used this study as basis for development manufacture contemporary decorative designs. In study,...

Almost all eukaryotic mRNAs have a poly (A) tail at the 3'-end. Canonical PAPs (PAPα/γ) polyadenylate nuclear pre-mRNAs. The recent identification of the non-canonical Star-PAP revealed specificity of nuclear PAPs for pre-mRNAs, yet the mechanism how Star-PAP selects mRNA targets is still elusive. Moreover, how Star-PAP target mRNAs having canonical AAUAAA signal are not regulated by PAPα is un...