The discovery of motifs underlying gene expression is a challenging one. Some of these motifs are known transcription factors, but sequence inspection often provides valuable clues, even discovery of novel motifs with uncharacterized function in gene expression. Coupled with the complexity underlying tissuespecific gene expression, there are several motifs that are putatively responsible for ex...

Biological motifs are defined as overly recurring sub-patterns in biological systems. Sequence motifs and network motifs are the examples of biological motifs. Due to the wide range of applications, many algorithms and computational tools have been developed for efficient search for biological motifs. Therefore, there are more computationally derived motifs than experimentally validated motifs,...

Résumé. Un certain nombre de travaux en fouille de données se sont intéressés à l’extraction de motifs et à la génération de règles d’association à partir de ces motifs. Cependant, ces travaux se sont jusqu’à présent, centrés sur la notion de motifs fréquents. Le premier algorithme à avoir permis l’extraction de tous les motifs fréquents est Apriori mais d’autres ont été mis au point par la sui...

Structural genomics initiatives are beginning to rapidly generate vast numbers of protein structures. For many of the structures, functions are not yet determined and high-throughput methods for determining function are necessary. Although there has been extensive work in function prediction at the sequence level, predicting function at the structure level may provide better sensitivity and pre...