نتایج جستجو برای: morphine sensitization

تعداد نتایج: 32486  

Journal: :physiology and pharmacology 0
ali akbar aliabadi hedayat sahraei department of physiology and biophysics, school of medicine, and behavioral sciences research center (bsrc), mehrangiz sadooghi hasan ghoshooni mehrvaz alaf-javadi seyed hasan salimi

introduction: the influence of ascorbic acid on the nicotine-induced conditioned place preference (cpp) and behavioral sensitization was investigated in the present study. methods: in a pilot study, place conditioning and locomotor activity were investigated after nicotine (0.25, 0.5, 0.75, 1, 1.5 and 2 mg/kg) or ascorbic acid (1, 10, 100 and 1000 mg/kg) administration. different doses of ascor...

2015
Saeed Esmaeili-Mahani Leila Satarian

Introduction: Regulators of G-protein signaling protein negatively control G protein -coupled receptor signaling duration by accelerating Gα subunit guanosine triphosphate hydrolysis . Since regulator of G-protein signaling4 has an important role in modulating morphine effects at the cellular level and the exact mechanism(s) of adrenalectomy-induced morphine sensitization have not been fully cl...

Journal: :Anesthesia and analgesia 2004
Chueng-He Lu Pei-Chieh Chao Cecil O Borel Chih-Ping Yang Chun-Chang Yeh Chih-Shung Wong Ching-Tang Wu

Cytokine release during surgery can produce a long-lasting hyperalgesia. Thus, preoperatively-administered cytokine inhibitors might reduce the production of cytokines, decreasing central nervous system sensitization and improving the quality of postoperative pain relief. We investigated the hypothesis that preincisional IV pentoxifylline (PTX) treatment could attenuate the release of proinflam...

2011
Boo Hwi Hong Wang Yong Lee Yoon Hee Kim Seok Hwa Yoon Won Hyung Lee

BACKGROUND Remifentanil is useful during general anesthesia because of its rapid onset and short acting time. However, some studies report that due to opioid-induced hyperalgesia (OIH) and tolerance, remifentanil also increases early postoperative pain. The occurrence of OIH and opioid-induced tolerance is mainly thought to be due to central sensitization by the activation of NMDA receptors. Th...

2010
V. Minville

Postoperative pain management is a great challenge because it is a critical part of a patient’s recovery. 2 Bone injury is often accompanied by acute pain that can be clearly diminished by morphine use. 4 However, although opioids are among the most effective analgesics in humans, there is growing evidence showing that they also induce abnormal and prolonged pain states after acute or chronic a...

Journal: :Sheng li xue bao : [Acta physiologica Sinica] 2012
Meng-Ling Chen Feng Bao Yu-Qiu Zhang Zhi-Qi Zhao

The previous study indicated that aquaporin 4 (AQP4) deficiency attenuated opioid physical dependence. However, the underlying mechanism remains unknown. In the present study, the effects of AQP4 deficiency on the expression of three factors, protein kinase C (PKC) α, PKCγ and c-Fos in the spinal cord, which are known to be concerned with spinal neuronal sensitization and opiate dependence, wer...

Journal: :Anesthesia and analgesia 2004
Wolfgang Koppert Marc Weigand Frank Neumann Reinhard Sittl Jürgen Schuettler Martin Schmelz Werner Hering

UNLABELLED Sodium channel blockers are approved for IV administration in the treatment of neuropathic pain states. Preclinical studies have suggested antihyperalgesic effects on the peripheral and central nervous system. Our objective in this study was to determine the time course of the analgesic and antihyperalgesic mechanisms of perioperative lidocaine administration. Forty patients undergoi...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2006
Emmanuel Valjent Anne-Gaëlle Corbillé Jesus Bertran-Gonzalez Denis Hervé Jean-Antoine Girault

Repeated association of drugs of abuse with context leads to long-lasting behavioral responses that reflect reward-controlled learning and participate in the establishment of addiction. Reactivation of consolidated memories is known to produce a reconsolidation process during which memories undergo a labile state. We investigated whether reexposure to drugs had similar effects. Cocaine administ...

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