BACKGROUND Diabetic foot ulcers (DFUs) are a devastating complication of diabetes. OBJECTIVES To identify genetic contributors to the development of DFUs in the presence of peripheral neuropathy in a Scottish cohort with diabetes using a genome-wide association study. METHODS A genome-wide association approach was applied. A case was defined as a person with diabetes (type 1 or type 2) who ...

Perceptual thresholds are known to vary across the foot sole, despite a reported even distribution in cutaneous afferents. Skin mechanical properties have been proposed to account for these differences; however, a direct relationship between foot sole afferent firing, perceptual threshold, and skin mechanical properties has not been previously investigated. Using the technique of microneurograp...

Sutures are used to close the cuts caused by injuries or to close the incision due to surgery and other medical procedures like wound approximation. They are commonly used on the skin, internal tissues, organs and blood vessels. They are available in the form of monofilament, multifilament/braided and pseudo monofilament. A lubricant is applied on the surface of braided suture material to lower...

BACKGROUND DPN is an important complication and contributes to the morbidity of diabetes mellitus. Evidence indicates early detection of DPN results in fewer foot ulcers and amputations. OBJECTIVE The purpose of this study was to compare different screening tests in the detection of DPN in primary care setting. METHODOLOGY It is a cross-sectional study in a random sample (N = 242) of type 2...

PURPOSE The objective of this study was to compare and evaluate the inflammatory responses of three widely used suture materials in the keratinized gingiva and buccal mucosa of beagle dogs. METHODS Silk, polyglycolic acid, and nylon sutures were placed within the mandibular keratinized gingiva and maxillary buccal mucosa of four male beagle dogs. Biopsies were taken 3, 7, and 14 days after su...

The effects of ultrasonic treatment (UST) on the solidification microstructure of a 35CrMo steel cast ingot were investigated. To avoid the erosion of a high-temperature melt, a T-shaped ultrasonic waveguide unit was used to introduce ultrasonic vibrations into a 35CrMo steel die casting melt. The experimental results show that the microstructure of the ingot was refined by ultrasonic treatment...