Monocytes and polymorphonuclear leukocytes (PMNLs) migrate across cytokine (interleukin-1, tumor necrosis factor) activated endothelium or unstimulated endothelium in response to chemotactic factors in vitro and in vivo utilizing the CD11/CD18 (i.e., beta 2 integrin) adhesion molecule complex. However, in vivo studies have suggested that under some conditions and/or in certain tissues, leukocyt...

We have previously shown that minimally oxidized LDL (MM-LDL) activated endothelial cells to increase their interaction with monocytes but not neutrophils, inducing monocyte but not neutrophil binding and synthesis of monocyte chemotactic protein-1 and monocyte colony-stimulating factor (M-CSF). In the present studies we have examined the signaling pathways by which this monocyte-specific respo...

Monocyte Chemotactic Protein-1 (MCP-1) as a Predictor of Prolonged Urinary Incontinence After Radical Prostatectomy Michael A. Liss, Thomas E. Ahlering, Blanca Morales, Adam Gordon, Kathryn Osann, Douglas Skarecky, Achim Lusch, Frank Zaldivar and Department of Urology, University of Texas Health Science Center San Antonio, TX, USA Department of Urology, University of California-Irvine, CA, USA ...

A recent study demonstrated that advanced glycation end products (AGEs) play a role in monocyte infiltration in mesangial areas in diabetic nephropathy. The Ras homolog gene family, member A Rho kinase (RhoA/ROCK) pathway plays a role in regulating cell migration. We hypothesized that the RhoA/ROCK pathway affects adhesion and inflammation in endothelial cells induced by AGEs. Rat glomerular en...

To explore the effect of Panax notoginseng saponins on atherosclerosis with type 2 diabetes mellitus in Goto-Kakizaki rats by nuclear factor-kappa B signaling pathway. fed high fat diet and injected N-nitro-L-arginine methyl ester for 8 w, were randomized into model group (400 mg/kg/d). Another Wistar selected as control which normal saline. Serum lipid inflammatory factors measured. There no s...

Statins have neuroprotective effects on neurological diseases, including a pleiotropic effect possibly related to blood–brain barrier (BBB) function. In this study, we investigated the of pitavastatin (PTV) lipopolysaccharide (LPS)-induced BBB dysfunction in an vitro model comprising cocultured primary mouse brain endothelial cells, pericytes, and astrocytes. LPS (1 ng/mL, 24 h) increased perme...