نتایج جستجو برای: monocyte chemoatractic protein 1

تعداد نتایج: 3629117  

Journal: :Circulation 2013
Israel F Charo

D espite the impressive success of statins in lowering cholesterol levels, atherosclerotic heart disease remains the leading cause of death in the Western world. Although a central role for cholesterol, particularly low-density lipoprotein cholesterol, in atherogenesis is undisputed, other contributing factors likely include diabetes mellitus, triglycerides, oxidation of proteins or lipids, and...

Journal: :iranian journal of public health 0
yongzhi lun 1. liaoning provincial university key laboratory of biophysics, college of medicine, dalian university dalian, china. chongbo xu 1. liaoning provincial university key laboratory of biophysics, college of medicine, dalian university dalian, china. qing chi 1. liaoning provincial university key laboratory of biophysics, college of medicine, dalian university dalian, china. xuelei wang 1. liaoning provincial university key laboratory of biophysics, college of medicine, dalian university dalian, china. wen sui 1. liaoning provincial university key laboratory of biophysics, college of medicine, dalian university dalian, china. sujuan jiang 2. department of gynecology and obstetrics, affiliated zhongshan hospital of dalian university , dalian, china.

hepatitis b virus (hbv) dna polymerase transactivated protein 1 (hbvdnaptp1) is a novel protein transactivated by hbv dna polymerase, screened by suppression subtractive hybridization technique (genbank accession no: ay450389). the biological function of hbvdnaptp1 was investigated in this study.we constructed a vector pcdna3.1 (-)/myc-his a-hbvdnaptp1 and used it to transfect acute monocytic l...

Journal: :The Journal of bone and joint surgery. British volume 1999
Y Nakashima D H Sun M C Trindade L E Chun Y Song S B Goodman D J Schurman W J Maloney R L Smith

Particulate wear debris is associated with periprosthetic inflammation and loosening in total joint arthroplasty. We tested the effects of titanium alloy (Ti-alloy) and PMMA particles on monocyte/macrophage expression of the C-C chemokines, monocyte chemoattractant protein-1 (MCP-1), monocyte inflammatory protein-1 alpha (MIP-1alpha), and regulated upon activation normal T expressed and secrete...

Journal: :Reviews in Cardiovascular Medicine 2022

Hypercholesterolemia is involved in the development of atherosclerosis and a risk factor for coronary artery disease, stroke, peripheral vascular disease. This paper deals with mechanism hypercholesterolemic atherosclerosis. increases formation numerous atherogenic biomolecules including reactive oxygen species (ROS), proinflammatory cytokines [interleukin (IL)-1, IL-2, IL-6, IL-8, tumor necros...

Journal: :Journal of applied physiology 2006
Christian K Roberts Dean Won Sandeep Pruthi Silvia Kurtovic Ram K Sindhu Nosratola D Vaziri R James Barnard

The present study was designed to examine the effects of lifestyle modification on key contributing factors to atherogenesis, including oxidative stress, inflammation, chemotaxis, and cell adhesion. Obese men (n = 31), 15 of whom had metabolic syndrome, were placed on a high-fiber, low-fat diet in a 3-wk residential program where food was provided ad libitum and daily aerobic exercise was perfo...

Journal: :Biochemical and biophysical research communications 1991
D DeMarco S L Kunkel R M Strieter M Basha R B Zurier

We report here that human synovial cells stimulated by interleukin-1 alpha and interleukin-1 beta express mRNA for both IL-8 (neutrophil chemotactic peptide) and monocyte chemotactic protein. IL-1 stimulated synovial cells from both osteoarthritis and rheumatoid arthritis patients exhibited similar mRNA expression of interleukin-8 and monocyte chemotactic protein. A capacity to produce factors ...

2014
DaShawn A. Hickman Gaurav Syal Michel Fausther Elise G. Lavoie Jessica R. Goree Brian Storrie Jonathan A. Dranoff

Portal fibroblasts (PF) are one of the two primary cell types contributing to the myofibroblast population of the liver and are thus essential to the pathogenesis of liver fibrosis. Monocyte chemoattractant protein-1 (MCP-1) is a known profibrogenic chemokine that may be of particular importance in biliary fibrosis. We examined the effect of MCP-1 on release of matrix metalloproteinase-9 (MMP-9...

Journal: :Circulation 2005
Ki Hoon Han Jewon Ryu Kyung Hee Hong Jesang Ko Youngmi Kim Pak Jae-Bum Kim Seong Wook Park Jae Joong Kim

BACKGROUND The migration of circulating monocytes to the arterial wall during atherogenesis is largely modulated by activation of the CC chemokine receptor 2 (CCR2), a dominant monocyte chemotaxis receptor. The present study investigated whether 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibition affects CCR2 gene expression and CCR2-dependent monocyte recruitment. METHODS AN...

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