Background Rheumatoid and Psoriatic Arthritis are both chronic inflammatory diseases of the joints characterized by synovial proliferation [1]. The JAK/STAT signalling pathway is critical in pathogenesis diseases, among them STAT3 activated numerous cytokines, growth factors, interferons Hypoxia also an important stimulus for activation consequent production accumulation HIF-1α, leading to neov...

We present the case of a patient with acute myelomonocytic leukemia with trisomy 8 and novel translocation t(5;13). In addition to acute leukemia she had debilitating left shoulder arthritis due to granulocytic sarcoma formation in the joint space. Her shoulder pain did not improve during induction chemotherapy but she experienced rapid relief of symptoms with use of local radiation. Her leukem...

INTRODUCTION Klebsiella pneumoniae septic arthritis and osteomyelitis, albeit uncommon in adults, are important sites of disseminated infection. Many case reports have shown K. pneumoniae as a cause of nosocomial transmitted septic arthritis in neonates and children. We report a rare case of an elderly patient with K. pneumoniae genitourinary infection spreading to the liver and other extra hep...