This study investigated whether trait-like differences in brain monoaminergic functioning relate to differential vulnerability for the long-term neurochemical depletion effects of MDMA. Genetically selected aggressive (SAL) and non-aggressive (LAL) house-mice differing in baseline serotonergic and dopaminergic neurotransmission were administered MDMA. An acute binge-like MDMA injection protocol...

In many species, successful reproduction is dependent on the ability to adjust social behavior in response to an ever-changing social environment. Because a sexual signal's value and meaning can differ between females and males, responses to those signals should also differ. One way individuals can modulate social behavior is through experience-dependent modulation of the sensory systems that p...

• We studied if monoamines underly variation in animal personality, crickets. Our monoamine manipulation via Fluphenazine lowered both boldness and exploration. show that effects can be dose- behaviour-dependent. Latency to emerge from shelter used as a measure of Behavioural results depend on the drug used. Despite prevalence research interest its underlying mechanisms are not yet fully unders...

In animals, sodium- and calcium-mediated persistent inward currents (PICs), which produce long-lasting periods of depolarization under conditions of low synaptic drive, can be activated in trigeminal motoneurons following the application of the monoamine serotonin. Here we examined if PICs are activated in human trigeminal motoneurons during voluntary contractions and under physiological levels...

Antidepressant drugs such as the serotonin (5-HT)/norepinephrine (NE) and dopamine (DA) reuptake inhibitors activate monoaminergic neurotransmission in various brain regions, such as the amygdala, the frontal cortex or the hippocampus. Although this property is well established, the post-synaptic mechanisms by which these pharmacological agents exert therapeutic activity in major depressive dis...

Vargas J1* and S1,2 Author Affiliations 1Laboratorio de Regeneración Neuronal, Instituto Nacional Rehabilitación SS, México 2FES-Zaragoza, UNAM, Received: April 26, 2022 | Published: May 25, Corresponding author: J, Laboratorio DOI: 10.26717/BJSTR.2022.44.006999