Chloropromazine (CPZ) and imipramine at a concentration of 1 x 10(-3) M inhibit rat brain mitochondrial monoamine oxidase activity in vitro by 70 and 55% respectively, while lithium, even at a concentration of 0.05 M, inhibits the activity of this enzyme very negligibly (4%). In vivo, these drugs at a dose level of 56 mg CPZ, 76 mg imipramine and 76 mg lithium chloride/Kg body wt., did not caus...

The morphine-induced changes in the activity of enzymes involved in the metabolism of neurotransmitters in specific areas of the brain of rats made tolerant to morphine have been investigated. The activities of choline acetyl transferase (E.G.2.3.1.6.), acetylcholinesterase (E.C.3.1.1.7.) and monoamine oxidase (E.G. 1.4.3.4.) were determined in the hippocampus, thalamus, hypothalamus, cerebral ...

Monoamine Oxidase Inhibitors DEAR SIR, Dr Pare's article on †̃¿ The Present Status of Monoamine Oxidase Inhibitors' is one of a genre that marks the renaissance of these drugs (Murphy et al, 1984; White & Simpson, 1985). This is understandable given that the †̃¿ second generation' compounds are less exciting than hoped, that early use of phenelzine was often with inadequate dosage and that im...

Although this human plasma enzyme was shown (1) to have certain characteristics in common with plasma amine oxidases from other mammals (2-6), it could be distinguished from these other plasma enzymes by its substrate specificity. During studies relating to the substrate specificity of the human enzyme, the oxidation of aliphatic amines was noted to have a number of distinctive kinetic features...

A screening study focusing on monoamine oxidase inhibitory activity on the EtOAc extract of an Ascomycete Chaetomium quadrangulatum, which previously gave five unique chromones possessing this activity (chaetoquadrins A-E (1-5)), this time afforded six new constituents termed chaetoquadrins F-K (6-11) in addition to 1-5. The structures of 6-11 have been deduced on the basis of spectral and chem...

Ongoing neuronal death in Parkinson's disease (PD) causes an altered neurotransmission of various biogenic amines, particularly dopamine. As these changes do not follow a distinct pattern, they vary individually, and are differently pronounced. As a result, a heterogeneous onset of motor and nonmotor features occurs in each patient with PD during the whole course of the disease. PD actually des...

Amine oxidases that occur in the plasma of mammals have been intensively studied in recent years (l-8). The ability of human plasma and serum to convert benzylamine to benzaldehyde has recently been demonstrated (9). Evidence has been presented to show that this enzymatic activity is different from other human plasma enzymes that catalyze the oxidation of amines (i.e. ceruloplasmin and diamine ...

living organisms. This class of enzymes is divided into two subclasses: FAD-containing amine oxidases (FAD-AOs) and Cu-containing amine oxidases (Cu-AOs). Two types of mitochondrial monoamine oxidases, monoamine oxidases (MAO)A and MAO-B, and cytosolic polyamine oxidase are included in FAD-AOs. The Cu-AOs consist of retina amine oxidase, diamine oxidase (DAO), and semicarbazide-sensitive amine ...