Neuronal migration is a fundamental component of brain development whose failure is associated with various neurological and psychiatric disorders. Reelin is essential for the stereotypical inside-out sequential lamination of the neocortex, but the molecular mechanisms of its action still remain unclear. Here we show that regulation of Notch activity plays an important part in Reelin-signal-dep...

Prenatal stress causes predisposition to cognitive and emotional disturbances and is a risk factor towards the development of neuropsychiatric conditions like depression, bipolar disorders and schizophrenia. The extracellular protein Reelin, expressed by Cajal-Retzius cells during cortical development, plays critical roles on cortical lamination and synaptic maturation, and its deregulation has...

Genetic improvement programs may improve disease resistance in animal production. The best-characterized genetic control of disease resistance and immune response in animals is the one associated with the Major Histocompatibility Complex (MHC). The ovine lymphocyte antigenof DRB1 gene encodes cell surface glycoproteins that initiate immune responses by presenting processed antigenic peptides to...

In this issue of Molecular Pharmacology, Kundakovic et al. (p. 644) present compelling evidence suggesting that the promoters for reelin and GAD67 are coordinately regulated. The regulation occurs at the level of DNA (cytosine-5) methylation. Moreover, the authors present evidence suggesting that pharmacologic inhibition of DNA methyltransferase results in reversal of methylation, loss of methy...

Reelin, a multifunctional extracellular protein that is important for mammalian brain development and function, is secreted by different cell types in the prenatal or postnatal brain. The spatiotemporal regulation of Reelin expression and distribution during development relates to its multifaceted function in the brain. Prenatally Reelin controls neuronal radial migration and proper positioning...

To successful molecular breeding, identification and functional characterization of breeding related genes and development of molecular breeding techniques using DNA markers are essential. Although the development of a useful marker is difficult in the aspect of time, cost and effort, many markers are being developed to be used in molecular breeding and developed markers have been used in many ...

background: the c1019t polymorphism of the connexin-37 (gja4) gene is a single-nucleotide polymorphisms involved in atherosclerotic plaque rupture and atherosclerosis predisposition. we examined the association between the c1019t polymorphism of the gja4 gene and the occurrence of myocardial infarction (mi) in patients with premature coronary artery disease (cad). methods: our study recruited 1...

IGF-I and IGFALS play a vital stimulator role in skeletal growth, cell differentiation, metabolism, other physiological processes. A total of 65 (male female) animals were used the study. Animals measured for growth traits at birth weight, weaning weights 6 months. The average daily gain (ADG) was calculated from to (ADG1) 6th month (ADG2). PCR-RFLP analysis detect polymorphism 5' regulatory re...

Ascochyta blight (caused by rabiei) is an important disease of chickpea. Mating type distribution, genetic diversity and population structure A. rabiei isolates from western Iran, using specific matting primers, ISSR SSR molecular markers. Two mating types were identified, with the 57% belonging to MAT1-1. Ten markers produced 78 polymorphic bands average polymorphism information content (PIC) ...