a Institute of Biophysics, Academy of Sciences of the Czech Republic, Královopolská 135, 612 65 Brno, Czech Republic; Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science, Palacky University, Olomouc, Tr. 17. Listopadu 12, 771 46 Olomouc, Czech Republic; Department of Chemistry, Single Molecule Analysis Group, University of Michigan, 930 N...

Modelling the packing of transmembrane helices: application to aquaporinI M. S. P. Sansom*’, I. D. Kerrt, R. Law*, L. Davison* and D. P. Tieleman* *Laboratory of Molecular Biophysics, University of Oxford, The Rex Richards Building, South Parks Road, Oxford OX I 3QU, U.K., tNuffield Department of Clinical Biochemistry, The University of Oxford, Institute of Molecular Medicine, John Radcliffe Ho...

1Center for Molecular Biotechnology, Department of Molecular Biotechnology and Health Sciences, 10126 Torino, Italy 2Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan 3Departments of Physiology and Biophysics and Medicine, University of Southern California, Los Angeles, CA 90033, USA 4Department of Internal Medicine, Jikei...

B. Iwan, J. Andreasson, M. Bergh, S. Schorb, H. Thomas, D. Rupp, T. Gorkhover, M. Adolph, T. Möller, C. Bostedt, J. Hajdu, and N.T̂ımneanu ∗ Laboratory of Molecular Biophysics, Institute of Cell and Molecular Biology Uppsala University, Husargatan 3, Box 596, S-75124 Uppsala, Sweden Institut für Optik und Atomare Physik, Technische Universität Berlin Eugene-Wigner-Bldg. EW 3-1, Hardenbergstrasse...

Duanxiang Xu, Gaohua Liu, Rong Xiao, Tom Acton, Sharon Goldsmith-Fischman, Barry Honig, Gaetano T. Montelione, and Thomas Szyperski* Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York Center of Advanced Biotechnology and Medicine and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey Howard Hughes Medical...

Guangyu Zhu, Jia Chen, Jay Liu, Joseph S Brunzelle, Bo Huang, Nancy Wakeham, Simon Terzyan, Xuemei Li, Zihe Rao, Guangpu Li and Xuejun C Zhang* Crystallography Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA, National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, Department of Biochemistry and Molecular Biol...

Gaohua Liu, Dinesh K. Sukumaran, Duanxiang Xu, Yiwen Chiang, Thomas Acton, Sharon Goldsmith-Fischman, Barry Honig, Gaetano T. Montelione, and Thomas Szyperski* Department of Chemistry, University at Buffalo, the State University of New York, Buffalo, New York Center of Advanced Biotechnology and Medicine and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New J...

Broad amplitude variability and skewed distributions are characteristic features of quantal synaptic currents (minis) at central synapses. The relative contributions of the various underlying sources are still debated. Through computational models of thalamocortical neurons, we separated intra- from extra-synaptic sources. Our simulations indicate that the external factors of local input resist...

Long-time molecular dynamics (MD) simulations are now able to fold small proteins reversibly to their native structures [Lindorff-Larsen K, Piana S, Dror RO, Shaw DE (2011) Science 334(6055):517-520]. These results indicate that modern force fields can reproduce the energy surface near the native structure. To test how well the force fields recapitulate the other regions of the energy surface, ...

From the Departments of Neuroscience & Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, the Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany, the Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Te...