AIMS To develop an assay which would determine the parentage of hydatidiform molar pregnancies. METHODS DNA was extracted from formalin fixed, paraffin wax embedded tissue from hydatidiform molar pregnancies and spontaneous abortions after separation of chorionic villi and decidua. PCR amplification of dinucleotide repeat sequences ("microsatellites") was performed using three different prime...

PURPOSE To describe the diffusion-weighted imaging (DWI) appearance of gestational trophoblastic disease (GTD) and to determine its apparent diffusion coefficient (ADC) values. To evaluate the feasibility of DWI to predict progression of hydatidiform mole (HM) to persistent disease. METHODS During a period of 6 months, women with preliminary diagnosis of GTD, based on ultrasound and ßhCG leve...

Background. The preferred treatment method of most hydatidiform moles is suction aspiration. In rare circumstances uterine abnormalities may preclude surgical treatment. Case. We report a case of complete molar pregnancy successfully treated with methotrexate followed by EMA/CO. A 38-year-old woman with a complete hydatidiform mole and multiple uterine fibroids underwent a failed attempt at suc...

background: repeated implantation failure (rif) is a major challenge in reproductive medicine and despite several methods that have been described for management, there is little consensus on the most effective one. objective: this study was conducted to evaluate the effectiveness of platelet-rich plasma in improvement of pregnancy rate in rif patients. materials and methods: twenty women with ...

case presentation our patient was a 32-year-old primigravid woman presented with abdominal and flank pain. her gestational age was 30 weeks. during admission in aria hospital, she had a significant hemoglobin level drop and developed signs of acute abdomen. conclusions laparotomy was performed and fundal uterine vessels rupture was seen and ligated. a 30-week-male fetus was born by cesarean sec...

Supervising Section Editor: Sean O. Henderson MD Submission history: Submitted July 20, 2012; Accepted July 30, 2012 Full text available through open access at http://escholarship.org/uc/uciem_westjem DOI: 10.5811/westjem.2012.7.12994 [West J Emerg Med 2013;14(2):121-122.] Amin Abdi, MD Shannon Stacy, MD Thomas Mailhot, MD Phillips Perera, MD Los Angeles County + University of Southern Californ...

During pregnancy, it is possible for the tissue surrounding the embryo to degenerate. Such degeneration typically manifests itself in hydatidiform moles and choriocarcinoma. These tumors are difficult to diagnose and are associated with an increased level of beta hCG. Treatment involves the complete removal of the tumorous growth. The characteristics of the tumors are described in more detail b...

Vaginal bleeding is the most common cause of presentation to the emergency department in the first trimester. Approximately half of patients with first trimester vaginal bleeding will lose the pregnancy. Clinical assessment is difficult, and sonography is necessary to determine if a normal fetus is present and alive and to exclude other causes of bleeding (eg, ectopic or molar pregnancy). Diagn...

Successful laboratory tests for early pregnancy utilize the endogenous production and excretion of chorionic gonadotrophin (CG). There is wide variation in sensitivity and specificity of various biological and commercially available immunochemical methods for determining urinary CC levels. Normal values for immunochemically reactive CC during the first trimester of pregnancy are given. Serial d...