3,6-Anhydro-l-galactose (AHG), a major monomeric constituent of red macroalgae (Rhodophyta), was recently reported to possess skin whitening activity. Moreover, AHG-containing oligosaccharides, such as agarooligosaccharides (AOSs) and neoagarooligosaccharides (NAOSs), have various physiological activities, including anti-inflammatory, antioxidant, and skin moisturizing effects. In this study, A...

Caryocar brasiliense, popularly known in Brazil as “pequi”, is a species widely distributed in the Brazilian Cerrado. The seeds are surrounded by a woody endocarp coated with a yellow fleshy mesocarp rich in oil and vitamin A, whose oil has a useful role in the treatment of skin aging and protection of human skin against UV-induced damage and skin hydration. The aim of this study was to evaluat...

Chenopodium formosanum Koidz (CF) is an indigenous cereal plant of Taiwan. Its high content secondary metabolites and nutrients has attracted attention for its use in skin care products functional foods. However, most studies have focused on the extract CF seeds, which are relatively expensive, none investigated effects combining extraction fermentation. In this study, we evaluated utility usin...

Epigallocatechin gallate (EGCG) is a catechin and an abundant polyphenol in green tea. Although several papers have evaluated EGCG as a cosmetic constituent, the skin hydration effect of EGCG is poorly understood. We aimed to investigate the mechanism by which EGCG promotes skin hydration by measuring hyaluronic acid synthase (HAS) and hyaluronidase (HYAL) gene expression and antioxidant and an...

To improve the disadvantages of existing water-soluble ascorbic acid (AsA) derivatives on their skin moisturizing effects, we added a laurylglyceryl group to AsA to produce 3-O-laurylglyceryl ascorbate (3LGA). In studies to assess the efficacy of 3LGA, we found that it had new functions not seen in AsA. Although 3LGA had less ability to scavenge reactive oxygen species (ROS), it elicited a supe...

Antioxidants contribute to endogenous photoprotection and are important for the maintenance of skin health. The study was carried out to compare the skin hydration and transepidermal water loss (TEWL) effects of a stable cosmetic preparation containing flavonoids, following two applications a day over a period of tenth week. The skin trans-epidermal water loss and skin hydration effect was meas...

BACKGROUND   Rosacea is a chronic inflammatory skin disease affecting mostly facial skin. Its origin is multifactorial. Important steps in its treatment are avoidance of any triggering factor and control of skin inflammation. AIM   To assess the benefit of topical applications of a new product (P-3075). PATIENTS/METHODS   A randomized, multicenter, double-blind, placebo-controlled, parallel...