OBJECTIVE To detect genes encoding carbapenem resistance in Acinetobacter baumannii in an intensive care unit. METHODS A. baumannii isolates were recovered from various clinical specimens of hospitalized patients admitted to the Medical and Surgical intensive care units of a tertiary care centre in Pune. Bacterial identification was performed by routine conventional microbial culture and bioc...

Carbapenemases production, either metallo-lactamases (MBLs), KPC or oxacillinases (OXA), is the main resistance mechanism responsible for resistance phenotype to carbapenems in Acinetobacter.1 While for MBLs and KPCs there are some screening tests for their detection,2,3 the same is not true for oxacillinases. During the investigation of a large outbreak, we analyzed 584 carbapenem-resistant Ac...

Background : Antibiotic resistance among Enterobacteriaceae posts a great challenge to the health care service. The emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) is attracting significant attention due to its rapid and global dissemination. The infection is associated with significant morbidity and mortality, thus creating challenges for infection control and managing teams to ...

Resistance to Tigecycline and/or Colistin among nosocomial pathogens is an emerging problem. Objective of the study was to record the drug susceptibility pattern of carbapenemase producing gram negative bacteria causing various nosocomial infections. This study was performed over six months from January to June2013 with 167 nonrepeat culture isolates causing various nosocomial infections.Antimi...

We prove that a variation of graded-polarizable mixed Hodge structure over a punctured disk with unipotent monodromy, has a limiting mixed Hodge structure at the puncture (i.e., it is admissible in the sense of [SZ]) which splits over R, if and only if certain grading of the complexified weight filtration, depending smoothly on the Hodge filtration, has a real limit at the puncture. In particul...

The goal of this paper is first of all to propose a strategy to attack the generalized Hodge conjecture for coniveau 2 complete intersections, and secondly to state a conjecture concerning the cones of effective cycle classes in intermediate dimensions. Our main results show that the generalized Hodge conjecture for coniveau 2 complete intersections would follow from a particular case of this e...

Introduction Part I: Hodge-theoretic analysis I.A. Notations and general background Review of material from [GGK] I.B. Integral symplectic linear algebra background I.C. Analysis of the LMHS in the three cases Part II. Boundary component structure II.A. Review of material from [KU] II.B. Boundary component structure for degenerations of Hodge structure of mirror quintic type Part III: Geometric...

R. Thomas (with a remark of B. Totaro) proved that the Hodge conjecture is essentially equivalent to the existence of a hyperplane section, called a generalized Thomas hyperplane section, such that the restriction to it of a given primitive Hodge class does not vanish. We show that the relations between the vanishing cycles have the same dimension as the kernel of the cospecialization morphism ...

In this chapter we will review a number of fundamental facts on the topology of smooth complex projective varieties, and the Hodge decomposition of their singular cohomology with complex coefficients. We will then see them in action by proving the Kodaira Vanishing theorem, the invariance of Hodge numbers under deformations, and the birational invariance of certain Hodge numbers. Some basic ref...

Let X be a smooth complex projective variety of dimension n. The Hodge conjecture is then true for rational Hodge classes of degree 2n−2, that is, degree 2n−2 rational cohomology classes of Hodge type (n − 1, n − 1) are algebraic, which means that they are the cohomology classes of algebraic cycles with Q-coefficients. Indeed, this follows from the hard Lefschetz theorem, which provides an isom...