The amounts of NG-methylarginine derivatives in myelin basic protein (MBP) purified from dysmyelinating mutant and different stages of normal myelinating mouse brains have been studied by using h.p.l.c. with a highly sensitive post-column o-phthaldialdehyde derivative-formation method. All three naturally occurring derivatives (NG-monomethylarginine (MeArg), NGN'G-dimethylarginine [Me2(sym)Arg]...

Guinea pig eosinophil granules are characterized by the presence of a basic protein of low molecular weight which accounts for greater than 50% of granule protein. This protein, termed the major basic protein (MBP), readily aggregates and becomes insoluble, and the formation of aggregates is dependent on the establishment of disulfide bonds. Analysis of concentrated preparations of MBP often re...

Mutations that reduce the net positive charge within the hydrophilic segments of the signal peptides of several prokaryotic exported proteins can result in a reduction in the rate of protein export, as well as a reduction in protein synthesis (M. N. Hall, J. Gabay, and M. Shwartz, EMBO J. 2:15-19, 1983; S. Inouye, X. Soberon, T. Franceschini, K. Nakamura, K. Itakura, and M. Inouye, Proc. Natl. ...

BACKGROUND Matrix metalloproteinases (MMPs) play a significant role in the fragmentation of myelin basic protein (MBP) and demyelination leading to autoimmune multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). The classic MBP isoforms are predominantly expressed in the oligodendrocytes of the CNS. The splice variants of the single MBP gene (Golli-MBP BG21 and J37) are ...

To achieve national and international climate goals, the greenhouse gas emissions from building sector must be reduced. One option is use of renewable energies, which stored. Building parts with thermal activation have potential to store heat. As those feature new active energetic functionalities – heat storage heating they are called multifunctional (MBP). investigate MBP, a model deployed ver...

The storage and processing of spatial information is done by spatial working memory. To measure spatial working memory, the Corsi blocks task, which separates the memory into two types, forward and backward, is often used. Although it had been thought that backward recall requires more of the executive function than forward recall, some studies have shown otherwise. Here, we focused on the spat...

The main purpose of designing multi-stage erbium-doped fiber amplifiers (EDFAs) is to achieve higher gain and lower noise figure for long haul optical communication. Among the multi-stage EDFAs, triple pass EDFAs were chosen in this research. This paper presents all possible triple pass EDFA configurations. The well-established one-stage mathematical models were modified to design two-stage and...

In this paper, a modified CDTA(MCDTA) is presented and the current-mode second-order band-pass, high-pass notch, and low-pass notch circuits using MCDTAs are given. Moreover, a current-mode sixth-order elliptic band-pass filter is realized by means of cascade method. Having used six MCDTAs, one CDTA, six grounded capacitors and two resistors, the circuit is easy to be integrated, of which the p...

A gene of the heavy-metal-binding protein (HMBP) was newly isolated from a genetic DNA library of activated-sludge microorganisms. HMBP was produced by transformed Escherichia coli, and the copper-binding ability of HMBP was confirmed. HMBP derived from activated sludge could be available as heavy metal adsorbents in water and wastewater treatments.

Serum mannose-binding protein (MBP) is a C-type lectin that binds to terminal mannose and N-acetylglucosamine moieties present on surfaces of certain pathogens and activates the classical complement pathway. In the present study, we describe the mechanism underlying the activation triggered by MBP. The human serum MBP fraction was obtained by sequential affinity chromatography on mannan-Sepharo...