Many prokaryotic organisms have adapted to incredibly extreme habitats. The genomes of such extremophiles differ from their non-extremophile relatives. For example, some proteins in thermophiles sustain high temperatures by being more compact than homologs in non-extremophiles. Conversely, some proteins have increased volumes to compensate for freezing effects in psychrophiles that survive in t...

Halophiles are extremophile organisms that thrive in environments with very high concentrations of salt. The salt mines of Karak region, is an extremely saline environment and its microbial communities have not yet been explored. In the present study, twenty one halotolerant and halophilic bacterial strains were isolated from salt mines of Karak region. These strains can grow in media with 5-40...

The genome of the halophilic archaeon Halobacterium sp. NRC-1 and predicted proteome have been analyzed by computational methods and reveal characteristics relevant to life in an extreme environment distinguished by hypersalinity and high solar radiation: (1) The proteome is highly acidic, with a median pI of 4.9 and mostly lacking basic proteins. This characteristic correlates with high surfac...

Innovative Solutions to Global Needs TECHNOLOGY CASE 1576 USPTO Links Introduction It would be difficult to overestimate the contribution of genetic manipulation to the study of any biological system, and it is an essential tool for the metabolic engineering of biosynthetic and substrate utilization pathways. This is particularly true for the archaea since, in spite of their environmental and i...

N-glycosylation of proteins is one of the most prevalent posttranslational modifications in nature. Accordingly, a pathway with shared commonalities is found in all three domains of life. While excellent model systems have been developed for studying N-glycosylation in both Eukarya and Bacteria, an understanding of this process in Archaea was hampered until recently by a lack of effective molec...

background and purpose: the goal of asthma therapy is to achieve clinical control and near normal lung functions. many patients with moderate persistent asthma fail to achieve this goal with a low dose of inhaled corticosteroid (ïçs) plus long-acting β2 agonist (lâbâ). ïn the present study, we have checked whether another controller medication (in the form of ginger capsule) add on to ïçslow do...

background: we aimed to observe the effect of holistic nursing on patients undergoing hematodialysis for uremia who simultaneously were suffering from moderate to severe malnutrition. methods: eighty patients with uremia on maintenance hematodialysis with malnutrition between june 2014 and june 2015 from yantaishan hospital, yantai, shandong, china were included and equally and randomly were di...

It is well known that supersymmetry (SUSY) gives neutron and electron electric dipole moments (dn and de) which are too large by about 10 . If we assume a SUSY model cannot contain fine-tunings or large mass scales, then one must require that the SUSY breaking mechanism give real soft breaking parameters, in which case the minimal SUSY model has no CP violation other than from the CKM matrix (b...

Extremely halophilic microorganisms that accumulate KCl for osmotic balance (the Halobacteriaceae, Salinibacter) have a large excess of acidic amino acids in their proteins. This minireview explores the occurrence of acidic proteomes in halophiles of different physiology and phylogenetic affiliation. For fermentative bacteria of the order Halanaerobiales, known to accumulate KCl, an acidic prot...

Halovirus is a major force that affects the evolution of extreme halophiles and the biogeochemistry of hypersaline environments. However, until now, the systematic studies on the halovirus ecology and the effects of salt concentration on virus-host systems are lacking. To provide more valuable information for understanding ecological strategies of a virus-host system in the hypersaline ecosyste...