The purpose of this study was to explore the effect of trastuzumab in enhancing the activity of chemotherapeutic agents and the molecular basis of this effect. Two gastric cancer cell types with HER2 amplification, one sensitive (NCI‑N87) and one insensitive (MKN-7) to trastuzumab, were tested for the effects of trastuzumab on cell growth and cell signaling using MTS assay and western blotting,...

Based on a weighted knowledge graph to represent first-order knowledge and combining it with a probabilistic model, we propose a methodology for the creation of a medical knowledge network (MKN) in medical diagnosis. When a set of symptoms is activated for a specific patient, we can generate a ground medical knowledge network composed of symptom nodes and potential disease nodes. By Incorporati...

CpG island promoter methylation of tumor suppressor genes is one of the most characteristic abnormalities in EBV-associated gastric carcinoma (GC). Aberrant promoter methylation and expression loss of PTEN were evaluated in cancer tissues of GC by methylation-specific PCR and immunohistochemistry, respectively, showing that both abnormalities occurred concurrently in EBV-associated GC. PTEN abn...

Bayesian solution of an inverse problem for indirect measurement M = AU + E is considered, where U is a function on a domain of R. Here A is a smoothing linear operator and E is Gaussian white noise. The data is a realization mk of the random variable Mk = PkAU + PkE, where Pk is a linear, finite dimensional operator related to measurement device. To allow computerized inversion, the unknown is...

Observations of the multi-TeV spectra of the nearby BL objects Mkn 421 and Mkn 501 exhibit the high energy cutoffs predicted to be the result of intergalactic annihilation interactions, primarily with infrared photons having a flux level as determined by various astronomical observations. After correction for this absorption effect, the derived intrinsic spectra of these multi-TeV sources can b...

The relationship between nonsteroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori-induced gastric mucosal injury is still under debate. VacA toxin is an important H. pylori virulence factor that causes cytoplasmic vacuolation in cultured cells. Whether and how NSAIDs affect VacA-induced cytotoxicity is unclear. This study was designed to evaluate the effect of NSAIDs on H. pylori V...

Since its commissioning in fall 1996, the stereoscopic system of Imaging Atmospheric Cherenkov Telescopes (IACTs) of HEGRA, with an energy flux sensitivity ν Fν at 1 TeV of 10−11 erg cm−2 s−1 for one hour of observation time, has been used to monitor the BL Lac object Mkn 421 on a regular basis. In this paper, we report detailed temporal and spectral information about the TeV characteristics of...

AIM To select the optimal antisense accessible sites of survivin, a highly expressed gene in tumor tissues, in order to explore a novel approach to improve biological therapy of gastric cancer. METHODS The 20 mer random oligonucleotide library was synthesized, hybridized with in vitro transcribed total survivin cRNA, then digested by RNase H. After primer extension and autoradiography, the an...