An estimation method based on RP-HPLC has been identified for determining the concentrations of pantoprazole sodium and mosapride citrate in combined pharmaceutical formulation. The experiment was performed on Hypersil BDS (4.6mm X 150nm), 5μm column in isocratic mode, with 1 mL/min flow of orthophosphoric acid adjusted, mobile phase consisting of a 40:60 mixture of mixed sodium phosphate buffe...

Widespread detection of pharmaceutical compounds in water environment has been a serious concern recently, while conventional sewage treatments are ineffective for their elimination. But, advanced oxidation techniques are very promising to remove varieties of organic contaminants in water. This research aims to elucidate oxidation potentials of sixteen commonly used pharmaceutical compounds in ...

In 2008, heparin (active pharmaceutical ingredient, API) lots were associated with anaphylactoid-type reactions. Oversulfated chondroitin sulfate (OSCS), a semi-synthetic glycosaminoglycan (GAG), was identified as a contaminant and dermatan sulfate (DS) as an impurity. While DS has no known toxicity, OSCS was toxic leading to patient deaths. Heparins, prepared before these adverse reactions, ne...

A simple, precise, specific ,robust and rapid HPLC assay for the of measurement meloxicam in pharmaceutical formulations was developed and validated at Department of Pharmacy and Central Quality Assurance Laboratory, LCWU, Lahore. The solution of meloxicam standard was prepared in HPLC grade acetonitrile (5 μg.mL) and ultra sonicated for 15 minutes. One mL sample mixed well with one mL of HPLC ...

Extracts from European mistletoe (Viscum album L.) developed in anthroposophic medicine are based on specific pharmaceutical procedures to enhance remedy efficacy. One such anthroposophic pharmaceutical process was evaluated regarding effects on cancer cell toxicity in vitro and on colchicine tumor formation in Lepidium sativum. Anthroposophically processed Viscum album extract (APVAE) was prod...

Roller compaction is a dry granulation technique used in the pharmaceutical industry, in which a powder formulation is compressed into a ‘ribbon’ compact between two counter rotating rolls. The ribbon is subsequently milled into granules of a desired size range. Whilst simple in principle, successful control of a roller compaction process is often difficult as it is multivariate in design. Furt...

Previous studies have demonstrated that pharmaceutical equivalence and pharmacokinetic equivalence of generic antibiotics are necessary but not sufficient conditions to guarantee therapeutic equivalence (better called pharmacodynamic equivalence). In addition, there is scientific evidence suggesting a direct link between pharmacodynamic nonequivalence of generic vancomycin and promotion of resi...

PURPOSE Piroxicam, is non-steroidal anti-inflammatory and analgesic agent, which is widely used in the treatment of patients with rheumatologic disorders. A new analytical approach based on the dispersive liquid-liquid microextraction (DLLME) has been developed for the extraction and determination of PX in pharmaceutical preparation and human urine. METHODS From the PX standard solution or so...

French pharmaceutical theses are rarely quoted. If the main obstacles originate from language or access barriers, proper indexation could also be blamed. Manually extracted key-words don't necessary come from a structured thesaurus. In the following work, this manual indexing method is compared to an automated one, "Nomindex", based on UMLS. The automated method is improved by the addition of a...

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