Histology revealed an atypical, densely cellular lymphoid infiltrate with a follicular growth pattern in the dermis and subcutaneous tissue (Figure 2). The infiltrate was composed of large cells resembling centroblasts or immunoblasts. Mitotic figures were common and the mitotic index was high. The immunohistochemical study was strongly positive for CD20, BCL-2 (Figure 3), and MUM-1/IRF4; weakl...

The genotoxic effects of the herbicide oxyfluorfen on root meristem cells Heianthus annuus L. (sunflower) were investigated. roots treated with 75, 150, and 300 ppm concentrations for 12 24 h. different genetic endpoints such as mitotic index (MI), chromosome aberrations (CA), micronuclei (MN) analyzed in both control test groups. showed a marked mitodepressive action mitosis. Additionally, MN ...

Castration of rats transplanted with the androgen-sensitive Dunning R3327-PAP prostituÃ--tumor results initially in a reduction of tumor growth, but after some time, some of the tumors start to grow again. The relapsed, androgen-insensitive PAP tumor shows a dedifferentiated mor phology. In the present study, we examined whether this androgen-independent tumor regrowth was due to an increased c...

We have previously reported that the retinoids, 4-(hydroxyphenyl)retinamide (4-HPR) and 9-cis-retinoic acid (RA) prevented azoxymethane (AOM)-induced colon tumors and along with 2-(carboxyphenyl)retinamide (2-CPR) prevented aberrant crypt foci (ACF). In this study, we evaluated the effect of 2-CPR on AOM-induced colon tumors and the effect of the three retinoids on apoptosis and cell proliferat...

The relationship between cell morphology, proliferation, and contact inhibition was studied in normal and malignant human cells which varied in their sensitivity to contact inhibition. Their ability to proliferate was examined under conditions where the cells were constrained into different shapes by plating onto plastic surfaces coated with poly(2-hydroxyethyl methacrylate). Poly(2-hydroxyethy...