Mitochondrial carriers are nuclear-encoded proteins, which translocate solutes across the inner mitochondrial membrane. functional as monomers and have six TM alpha-helices termini in intermembrane space.

Background: Varicocele is the abnormal tortuosity and dilatation of the veins of the pampiniform plexus within the spermatic cord. Varicocele-related pathology is suspected in infertility as it leads to elevated temperatures in the scrotum and testes, which has a deleterious effect on spermatogenesis. In Varicocele patients, ROS production is enhanced and total antioxidant capacity (TAC) is red...

in this research, we investigated the cytotoxic mechanisms of cochlodinium polykrikoidescell lysate on isolated rat liver hepatocytes.this micro algae is responsible for a severe and widespread harmful algal bloom in the persian gulf and gulf of oman (2008-2009). isolated hepatocytes were obtained by collagenase perfusion of sprague-dawley rat liver.according to our results, incubation of algal...

objective(s) the mitochondrial defects in friedreich's ataxia have been reported in many researches. mitochondrial dna is one of the candidates for defects in mitochondrion, and complex i is the first and one of the largest catalytic complexes of oxidative phosphorylation (oxphos) system. materials and methods we searched the mitochondrial nd4l gene for mutations by ttge and sequencing on ...

the persian sturgeon, acipenser persicus (borodin, 1897), is an economically important species, which mainly inhabits the caspian sea. however, little is known about its population genetic structure. in this study, variation in nucleotide sequences of the mitochondrial dna (mtdna) control region of wild stock persian sturgeon was determined to assess the genetic diversity among different natura...

two nuclear microsatellite dna loci along with partial sequences of mitochondrial dna trna pro -d-loop region were analyzed to assess the genetic diversity and population genetic structure of spottybelly greenling ( hexagrammos agrammus ). a total of 85 individuals were investigated from two different locations at the east and the south coasts of korea which are imwonjin (im) and tongyeong (tn)...

introduction: neurodegenerative diseases are progressive disorders that could impair neuronal functions and structures. oxidative stress and mitochondrial dysfunction are involved in the etiology of neurodegenerative diseases such as alzheimer’s disease, parkinson’s disease and etc. gemfibrozil is used as a therapeutic drug for hyperlipidemia. it has been shown that gemfibrozil is neuroprotecti...

paraschistura alta , formerly reported from the eastern part of sistan basin in afghanistan, is reported for the first time from the zahak river in iranian part of this basin and its morphological characteristics, coi barcode and its phylogenetic relationship within other members of the genus paraschistura from iran are provided. all the measured meristic and morphometric characters of seven co...

Objective(s) The mitochondrial defects in Friedreich's ataxia have been reported in many researches. Mitochondrial DNA is one of the candidates for defects in mitochondrion, and complex I is the first and one of the largest catalytic complexes of oxidative phosphorylation (OXPHOS) system. Materials and Methods We searched the mitochondrial ND4L gene for mutations by TTGE and sequencing on 30...

In this research, we investigated the cytotoxic mechanisms of one of the widely used pharmaceuticals that are regularly associated with the adverse effects on the liver, sometimes leading to acute liver failure, diclofenac. Diclofenac liver cytotoxicity was associated with reactive oxygen species (ROS) formation and lipid peroxidation which were inhibited by antioxidants and ROS scavengers, fer...