Four experiments examined Dutch listeners' use of suprasegmental information in spoken-word recognition. Isolated syllables excised from minimal stress pairs such as VOORnaam/voorNAAM could be reliably assigned to their source words. In lexical decision, no priming was observed from one member of minimal stress pairs to the other, suggesting that the pairs' segmental ambiguity was removed by su...

The Mismatch Negativity (MMN) response has often been used to measure memory traces for phonological representations and to show effects of long-term native language (L1) experience on neural organization. We know little about whether phonological representations of non-native (L2) phonemes are modulated by experience with distinct non-native accents. We used MMN to examine effects of experienc...

I n hereditary non-polyposis colorectal cancer (HNPCC), the most common form of inherited colorectal cancer, detection of the causal alteration of the mismatch repair (MMR) gene involved is essential for proper management of the families. This will allow the identification of relatives with high risk for colorectal or endometrial cancer, who require the appropriate screening and, conversely, wi...

Recombinational repair of a site-specific, double-strand DNA break (DSB) results in increased reversion frequency for nearby mutations. Although some models for DSB repair predict that newly synthesized DNA will be inherited equally by both the originally broken chromosome and the chromosome that served as a template, the DNA synthesis errors are almost exclusively found on the chromosome that ...

Mismatch repair (MMR) is activated by evolutionarily conserved MutS homologs (MSH) and MutL homologs (MLH/PMS). MSH recognizes mismatched nucleotides and form extremely stable sliding clamps that may be bound by MLH/PMS to ultimately authorize strand-specific excision starting at a distant 3'- or 5'-DNA scission. The mechanical processes associated with a complete MMR reaction remain enigmatic....

Three processes act in series to accurately replicate the eukaryotic nuclear genome. The major replicative DNA polymerases strongly prevent mismatch formation, occasional mismatches that do form are proofread during replication, and rare mismatches that escape proofreading are corrected by mismatch repair (MMR). This review focuses on MMR in light of increasing knowledge about nuclear DNA repli...

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