نتایج جستجو برای: mird method
تعداد نتایج: 1630212 فیلتر نتایج به سال:
UNLABELLED Renal toxicity associated with small-molecule radionuclide therapy has been shown to be dose-limiting for many clinical studies. Strategies for maximizing dose to the target tissues while sparing normal critical organs based on absorbed dose and biologic response parameters are commonly used in external-beam therapy. However, radiopharmaceuticals passing though the kidneys result in ...
Phantoms for radiation dosimetry, including physical phantoms for radiological use in medicine in particular, were introduced as early as the 1910s [1] while those for radiation protection dosimetry started to evolve in the late 1950s. This innovation was driven partly from the consensus that dose quantity for protection purposes should be assessed in “receptor conditions” instead of the tradit...
Introduction: Nowadays, radioisotopes have a lot of therapeutic and diagnostic applications in nuclear medicine. The technetium-99m radioisotope is widely used in the diagnostic field. The technetium-99m radioisotope is widely used in the diagnostic field. In this study, in order to increase the absorption dose in thyroid cancer cells, the radioactive drug technetium-99m which ...
چکیده ندارد.
This report describes recommended techniques for radiopharmaceutical biodistribution data acquisition and analysis in human subjects to estimate radiation absorbed dose using the Medical Internal Radiation Dose (MIRD) schema. The document has been prepared in a format to address two audiences: individuals with a primary interest in designing clinical trials who are not experts in dosimetry and ...
UNLABELLED As one of the major organs of the excretory pathway, the kidneys represent a frequent source of radiopharmaceutical uptake in both diagnostic and therapeutic nuclear medicine. The unique organization of the functional tissues of the organ ensures transient changes in suborgan localization of renal activity. Current single-region dosimetric models of the kidneys, however, force the as...
زمینه: مقدار زیادی از رادیوداروهای تجویز شده برای درمان و تشخیص بیماری از طریق کلیه دفع میشود، بنابراین دوز ناخواسته تابش در کلیه ایجاد میشود. پس محاسبه دقیق مقدار داروی تجویز شده اهمیت دارد. در جزوه 5-MIRD کلیه بهصورت بیضیگون در نظر گرفته شده که رادیودارو بهصورت یکنواخت در حجم آن توزیع شده و کسر جذب گاما محاسبه و در جداولی ثبت شده و کسر جذب بتا واحد در نظر گرفته شده است. در صورتیکه کلیه ...
The thymus gland is an endocrine gland that plays an important role in the body’s immunity. Thymus gland cancer happens very rarely and one treatment way is radiation therapy. Due to the location of this gland and its proximity to the sensitive organs, radiation therapy of thymus gland cancer will bring the risk of side effects. In this paper, a Mird phantom is simulated and a modulator and ran...
UNLABELLED Technical aspects and results of the dosimetric assessments of postoperative radioiodine ablation in the framework of an international, prospective, controlled, randomized, comparative study of the effectiveness of ablation therapy with 3.7 GBq (131)I in differentiated thyroid cancer after stimulation with recombinant human TSH (rhTSH) or by thyroid hormone withdrawal (THW) are prese...
Calculation of the therapeutic activity of radioiodine (131)I for individualized dosimetry in the treatment of Graves' disease requires an accurate estimate of the thyroid absorbed radiation dose based on a tracer activity administration of (131)I. Common approaches (Marinelli-Quimby formula, MIRD algorithm) use, respectively, the effective half-life of radioiodine in the thyroid and the time-i...
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