نتایج جستجو برای: mird
تعداد نتایج: 217 فیلتر نتایج به سال:
2-((2-((Dimethylamino)methyl)phenyl)thio)-5-123I-iodophenylamine (123I-ADAM) is a new radiopharmaceutical that selectively binds the central nervous system serotonin transporters. The purpose of this study was to measure its whole-body biokinetics and estimate its radiation dosimetry in healthy human volunteers. The study was conducted within a regulatory framework that required its pharmacolog...
دزیمتری تابش داخلی رادیوداروها، از جنبههای مهم در پزشکی هسته ای برای سنجش میزان خطر در برابر کاربردهای مفید است. درمان با رادیوید یک روش موثر و ایمن در درمان بیماران با سرطان های مختلف تیروئید (dtc) بعد از جراحی غده تیروئید محسوب می شود. هدف از این مطالعه توصیف روشی جهت تخمین دز جذب شده به خون و اکتیویته تجویزی با استفاده روش های دزیمتری تابش داخلی پزشکی mird می باشد. روش کار: این مطالعه 26 ...
Introduction: Now day Ionizing radiation has found increasing applications in cancer treatment. However, in the treatment different kinds and size of tumors especially metastatic and small size tumors, conventional methods of external radiation therapy are not common. In radionuclide therapy, the use of monoclonal antibodies has made it possible to achieve maximum dose to small size tumor and m...
Currently, the validation of multimodal quantitative imaging and absorbed dose measurements is impeded by the lack of suitable, commercially available anthropomorphic phantoms of variable sizes and shapes. To demonstrate the potential of 3-dimensional (3D) printing techniques for quantitative SPECT/CT imaging, a set of kidney dosimetry phantoms and their spherical counterparts was designed and ...
UNLABELLED The aim of this study was to investigate the pharmacokinetics, organ dosimetry, and toxicity after the intraarterial administration of (188)Re-labeled 4-hexadecyl-1,2,9,9-tetramethyl-4,7-diaza-1,10-decanethiol/lipiodol ((188)Re-HDD/lipiodol) for palliative treatment of hepatocellular carcinoma (HCC). A secondary objective was to document the response. METHODS A mean activity of 3.6...
BACKGROUND Circadian variation of gene expression is often neglected when ionizing radiation-induced effects are studied, whether in animal models or in cell culture. This study characterized diurnal variation of genome-wide transcriptional regulation and responses of potential biomarkers and signature genes in normal mouse tissues at 24 h after i.v. administration of (131)I. METHODS Female B...
UNLABELLED In targeted radionuclide radiotherapy, the relationship between bone marrow (BM) toxicity and absorbed dose seems to be elusive. A compartmental model of mouse thrombopoiesis and erythropoiesis was set up to predict the depletion of hematopoietic cells as a function of the irradiation dose delivered to BM by injected radiopharmaceuticals. All simulated kinetics were compared with exp...
Objective(s):Lutetium-177 can be made with high specific activity and with no other isotopes of lutetium present, referred to as “No Carrier Added” (NCA) 177Lu. We have radiolabelled DOTA-conjugated peptide DOTA‐(Tyr3)‐octreotate with NCA 177Lu (“NCA-LuTATE”) and used it in nearly 40 therapeutic administrations for subjects with neuroendocrine tumours or meningiomas. In this paper, we report on...
Background: Recent pre-clinical and clinical studies indicate that irradiation in the dose range of 15 to 30 Gy can reduce rate of restenosis in patients who have undergone an angioplasty. The use of filled balloon with radioactive solution was proposed as one of the possible intravascular irradiation techniques. Materials and Methods: The Monte Carlo N-particle Transport Code (MCNP4b) was used...
Introduction: Recently head and neck cancer has pay attention to many researchers. Its therapeutic methods include surgery, chemotherapy, radiotherapy and Boron neutron capture therapy (BNCT). BNCT is better than conventional radiotherapy because it targets the tumor cell. This method involves two steps of infusion of stable 10B and then neutron radiation with a suitable intens...
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