نتایج جستجو برای: mir 182 5p

تعداد نتایج: 56569  

Journal: :Molecular medicine reports 2015
Duqun Chen Yuchi Li Zuhu Yu Yifan Li Zhengming Su Liangchao Ni Shangqi Yang Yaoting Gui Yongqing Lai

MicroRNA (miR)-510-5p has been demonstrated to be involved in a number of types of malignancy; however, the function of miR-510-5p in renal cancer remains unclear. The present study aimed to determine the expression of miR-510-5p in renal cell carcinoma (RCC) specimens and analyzed the impact of miR-510-5p on renal cancer by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, wound sc...

2017
Zhiyuan Wang Chao Jiang Xiaobo Chang Yahui Dai

Osteosarcoma is one of the most leading causes of cancer-related mortality in children and adolescence around the world. The aim of this study was to determine the clinical value of miR-491-5p in osteosarcoma. Quantitative real-time PCR was used to evaluate miR-491-5p level in the tissue/serum samples from patients with osteosarcoma. Then the clinical significance of tissue/serum miR-491-5p was...

2016
Kihwan Lee Hyunju Kim Kyongman An Oh-Bin Kwon Sungjun Park Jin Hee Cha Myoung-Hwan Kim Yoontae Lee Joung-Hun Kim Kwangwook Cho Hye-Sun Kim

MicroRNAs have emerged as key factors in development, neurogenesis and synaptic functions in the central nervous system. In the present study, we investigated a pathophysiological significance of microRNA-188-5p (miR-188-5p) in Alzheimer's disease (AD). We found that oligomeric Aβ1-42 treatment diminished miR-188-5p expression in primary hippocampal neuron cultures and that miR-188-5p rescued t...

2018
Chang-Long He Ming Liu Zhao-Xia Tan Ya-Jun Hu Qiao-Yue Zhang Xue-Mei Kuang Wei-Long Kong Qing Mao

AIM To investigate the mechanism by which hepatitis C virus (HCV) core protein-induced miR-93-5p up-regulation regulates the interferon (IFN) signaling pathway. METHODS HCV-1b core protein was exogenously expressed in Huh7 cells using pcDNA3.1 (+) vector. The expression of miR-93-5p and interferon receptor 1 (IFNAR1) was measured using quantitative reverse transcription-polymerase chain react...

2014
Heejeong Lee Kyu Rae Kim Nam Hoon Cho Sung Ran Hong Hoiseon Jeong Sun Young Kwon Kwang Hwa Park Hee Jung An Tae Heon Kim Insun Kim Hye Kyoung Yoon Kwang Sun Suh Ki Ouk Min Hyun Joo Choi Ji Young Park Chong Woo Yoo Youn Soo Lee Hee Jin Lee Weon Sun Lee Chul Soo Park Yonghee Lee

BACKGROUND MicroRNA (miRNA) expression is known to be deregulated in cervical carcinomas. However, no data is available about the miRNA expression pattern for the minimal deviation adenocarcinoma (MDA) of uterine cervix. We sought to detect deregulated miRNAs in MDA in an attempt to find the most dependable miRNA or their combinations to understand their tumorigenesis pathway and to identify di...

2015
Gongbin Lan Luoyan Yang Xubiao Xie Longkai Peng Yi Wang

INTRODUCTION Recent studies have demonstrated the critical roles of micro-RNAs in tumorigenesis and tumor progression. Here, we describe the regulation and function of miR-490-5p in bladder cancer. MATERIAL AND METHODS Paired tissue samples were collected from bladder cancer patients (n = 20). Real-time PCR revealed that miR-490-5p expression was significantly down-regulated in human bladder ...

Journal: :Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015
Xuecai Niu Sen Liu Li Jia Jing Chen

BACKGROUND/AIMS The malignancy of non-small cell lung cancer (NSCLC) is largely due to its fast growth and invasion. WNT/β-catenin signaling plays a critical role in regulating NSCLC carcinogenesis. Hence, suppression of β-catenin signal transduction in NSCLC cells may improve the therapeutic outcome. METHODS We analyzed the levels of β-catenin and miR-3619-5p in NSCLC specimens, compared to ...

2017
Jing Zhang Zhonglin Zhu Jinxin Sheng Zhilong Yu Bin Yao Kejian Huang Lisheng Zhou Zhengjun Qiu Chen Huang

BACKGROUND Our study aimed to investigate the clinicopathological feature and prognostic role of miR-509-3-5P in gastric cancer, to determine the invasive and metastatic role of miR-509-3-5P in vitro and in vivo and to explore the molecular mechanism between miR-509-3-5P and PODXL. RESULTS Strikingly lower miR-509-3-5P expression was detected in gastric cancer tissues with advanced tumor stag...

2017
Fang Cao Qiang Zhang Wei Chen Feng Zheng Qishan Ran Yang He Yang Gao Shengtao Yao

Gene associated with retinoid-interferon-induced mortality-19 (GRIM-19) has been recognized as a tumor suppressor protein, which regulates cell growth, apoptosis, and migration by signal transducer and activator of transcription 3 (STAT3) signaling pathway and non-STAT3 pathway in glioma cells. Here, we investigated the molecular mechanisms that regulated GRIM-19 expression in glioma cells. By ...

Journal: :Cancer research 2013
Filipa G Pinho Adam E Frampton Joao Nunes Jonathan Krell Heba Alshaker Jimmy Jacob Loredana Pellegrino Laura Roca-Alonso Alexander de Giorgio Victoria Harding Jonathan Waxman Justin Stebbing Dmitry Pchejetski Leandro Castellano

Sphingosine kinase 1 (SK1) plays an important role in estrogen-dependent breast tumorigenesis, but its regulation is poorly understood. A subset of microRNAs (miRNA, miR) is regulated by estrogen and contributes to cellular proliferation and cancer progression. Here, we describe that miR-515-5p is transcriptionally repressed by estrogen receptor α (ERα) and functions as a tumor suppressor in br...

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