By testing archival paraffinized biopsy blocks obtained from the oral pathology library with immunohistochemistry, we tested the hypothesis that substantial alterations are demonstrable in the cross-talk between sympathetic (VMAT) and para-sympathetic innervation (VAchT), and resident CD3+ T cells in the mucosa from oral lichen planus (OLP), compared to recurrent aphthous stomatitis (RAS) and c...

BACKGROUND Gluten sensitive enteropathy (GSE) is an autoimmune enteropathy triggered by the ingestion of gluten-containing grains in susceptible individuals. Recurrent aphthous stomatitis (RAS) may be the sole manifestation of GSE. The aim of this study was to determine the prevalence of gluten sensitivity enteropathy (GSE) in a large group of patients with RAS and assess the efficacy of gluten...

Recurrent Aphthous Stomatitis (RAS) is a disorder characterized by recurring ulcers in the oral mucosa in patients with no other signs of disease. This condition is also called as Sutton’s disease, especially in the case of major, multiple or recurring ulcers. RAS appears to represent several pathological states with similar clinical manifestations, including immunologic disorders, hematologic ...

Introduction Recurrent aphthous stomatitis (RAS) is a common chronic inflammatory oral mucosa disease with an unknown cause. However, dysregulation of the immune response seems to play an important role in this disease. Aim To evaluate the vitamin D status in RAS patients and its effects on RAS severity, given the likely immunomodulatory function of vitamin D in the human organism. Material...

Diverticulitis is a well-established complication of diverticulosis. Data regarding the endoscopic appearance of diverticulitis are limited, as colonoscopy is generally contraindicated during the acute attack, due to the increased risk of complications, especially bowel perforation. Endoscopic signs of inflammation in patients with diverticulosis are limited to the segments having the diverticu...

A variety of extraintestinal manifestations, probably immune-mediated, may appear during relapses of Crohn's disease. We report the clinical observation of a 34-year-old woman who developed a Guillain-Barré syndrome, aphthous stomatitis and oligoarthritis during a relapse of Crohn's ileocolitis. This case suggests that the Guillain-Barré syndrome may be another extraintestinal manifestation of ...

We describe an 18-year-old man with a 7-year history of severe major aphthous stomatitis refractory to multiple standard therapies who responded completely to therapy with adalimumab, a fully humanized monoclonal antibody against tumor necrosis factor alpha (TNF-alpha).

Mukhapaka (Stomatitis) is a common ailment seen in general practice. The Pittaja (Aphthous ulcer) fully described Ayurveda under the term Mukha rogas. Oral ulcers are estimated to impact 4% of global population, with aphthous being most frequent, affecting up 25% population. Psychological stress, hormonal impacts, dietary sensitivity, and nutritional insufficiency primary causes ulcer). It pain...