The effects of myristyl nicotinate (MN), a nicotinic acid derivative designed to deliver nicotinic acid to skin without vasodilatation, on subjects with photodamaged skin have been studied. MN increased skin cell nicotinamide adenine dinucleotide (NAD) by 25% (P = 0.001) demonstrating effective delivery of nicotinic acid to skin. Relative to placebo, MN treatment of photodamaged facial skin inc...

Exposure to ultraviolet radiation (UVR) during childhood reduces the likelihood of developing auto-immune disease, but increases the risk of developing melanoma. As immune suppression is likely to contribute to both of these alterations, we propose that exposure to UVR during the neonatal period modifies development of the immune system. To test this hypothesis, neonatal mice were exposed to a ...

Background: Carnosine is a low molecular weight water soluble biological dipeptide, composed of alanine and histidine, present in a levorotatory form in mammalian tissues. Interesting activities are related to the detoxification from free radical species and byproducts of membrane lipids peroxidation. Objectives: The aim of the present study was to evaluate the photoprotective properties of car...

introduction: skin dose and depth dose distribution of some beta sources that can contaminate skin or protective clothing covering the skin have been calculated using varskin2. materials and methods: in this research, absorbed dose to skin and depth dose from the skin surface have been calculated for 90sr/90y, 147pm, 32p beta emitter radioisotopes by using input parameters: activity of source, ...

Background: To evaluate the dosimetric difference between conventional and three-dimensional conformal Radiotherapy (3D-CRT) using 6 and 18 MV X-ray photons. Materials and Methods: Computed tomography scans of 26 pelvic patients were acquired and transferred to the 3D treatment planning system. For each patient, 8 Conventional plans (3, 4, 5 and 6 Fields) and one 3D-CRT plan were prep...

The optical properties of poly(2,6-dimethyl-1,4-phenylene oxide) (PPO) film have been characterized in order to develop an alternative method for UV dosimetry with a focus on long-term human exposure measurements. The dynamic range of PPO film was found to extend to 2 MJ m(-2) of broadband UV exposure independently of film thickness, providing an exposure range of roughly four summer days at su...

BACKGROUND The pathogenic mechanisms of UV-induced skin lesions of lupus erythematosus (LE) are unknown. In a recent study of pathogenic mechanisms of polymorphic light eruption (PLE), significantly more Langerhans cells (LCs) persisted in the epidermis after UVB overexposure than in healthy individuals. Interestingly, the same phenomenon was observed in one subacute cutaneous lupus erythematos...

According to the Shadow Rule (SR), an individual can control the time of exposure to the Sun observing the body’s shadow length on a horizontal surface. Although a simple rule, the SR depends primarily on the ozone column (O3) amount, which can complicate the application of this rule in scenarios of lower O3 amounts like those in the low latitudes of Southern Hemisphere. The SR by itself can be...

BACKGROUND  In radiosurgery, the convention has been to prescribe radiation dose to a "covering isodose volume". This is presumed to be the minimum dose received by the entire tumor. Our purpose was to review our practice, assess different means of specifying a prescription isodose, and test how reliable they were in the face of various calculation methodologies. METHODS Different minimum dos...