We recently succeeded in purifying a novel multipotential progenitor or stem cell population from bone marrow stromal cells (BMSCs). This population exhibited a very high frequency of colony forming units-osteoblast (CFU-O; 100 times higher than in BMSCs) and high expression levels of osteoblast differentiation markers. Furthermore, large masses of mineralized tissue were observed in in vivo tr...

Large calcified areas were observed in the articular discs of the temporomandibular joint from five patients suffering from articular dysfunctions. The calcified regions were always located inside the fibrous tissue of the discs. They had a woven bone-like morphological pattern and consisted of a compact mineralized tissue containing cells in irregular lacunae. In all the samples the calcified ...

biogeochemistry is a useful tool for assessing geochemical dispersion patterns. sari gunay epithermal gold deposit was selected in order to assess the application of biogeochemical exploration for gold in northwestern iran. in this study, four sites were sampled in a profile perpendicular to mineralized vein with a control site two km far-off mineralized vein. a sample from each dominant plant ...

The water quality parameters of the river Damodar flowing across the coal mines and industrial area was carried out in order to evaluate its suitability of irrigation application. Damodar River basin is the repository of 46% coal reserves in India and is one of the richest mineralized zones of the country with a high growth of mining and industrial development, demographic and urban growth exte...

Although the responses of bone to increased loading or exercise have been studied in detail, our understanding of the effects of decreased usage of the skeleton has been limited by the scarcity of suitable models. Such models should ideally not affect bone innervation, which appears to be a mediator of physiological responses of bone to unloading. MyoD-/-/Myf5-/- (dd/ff) mice lack skeletal musc...

Extracellular matrix mineralization is an essential physiologic process in bone, teeth, and hypertrophic cartilage. Matrix Gla protein (MGP), an inhibitor of mineralization, is expressed by chondrocytes and vascular smooth muscle cells to inhibit calcification of those soft tissues. Tibial dyschondroplasia (TD), a skeletal abnormality apparent as a plug of non-vascularized, non-mineralized, whi...