Zebrafish (ZF, Danio rerio) has emerged as an important and popular model species to study different human diseases. Key regulators of skeletal development and calcium metabolism are highly conserved between mammals and ZF. The corresponding orthologs share significant sequence similarities and an overlap in expression patterns when compared to mammals, making ZF a potential model for the study...

The purpose of this study was to determine which factor is the most likely one to have stimulated the mineralization process in the in vitro experiments of Klein-Nulend et al. (Arth. Rheum., 29, 1002-1009, 1986), in which fetal cartilaginous metatarsals were externally loaded with an intermittent hydrostatic pressure, by compressing the gas phase above the culture medium. Analytical calculation...

The effect of breeding from the white rot fungus Phanerochaete chrysosporium ME446 on performance for lignin mineralization was examined. This model for informed strain improvement without mutagenesis is based on abundant restriction fragment length polymorphisms (RFLPs). Under optimized conditions for lignin mineralization, extracellular manganese peroxidase (MnP) but not lignin peroxidase (Li...

Endochondral ossification is a carefully orchestrated process mediated by promoters and inhibitors of mineralization. Phosphatases are implicated, but their identities and functions remain unclear. Alkaline phosphatase (TNAP) plays a crucial role promoting mineralization of the extracellular matrix by restricting the concentration of the calcification inhibitor inorganic pyrophosphate (PP(i)). ...

The purpose of this study was to investigate the relation between bone tissue stiffness and degree of mineralization distribution and to examine possible changes during prenatal development. Understanding this may provide insight into adaptation processes and into deformation mechanisms of the bone microstructure. Mandibular condyles from four fetal and newborn pigs were used. Tissue stiffness ...

This study investigates the significance of the expression and dynamics of podoplanin in mechanostress and mineralization in cultured murine osteoblasts. Podoplanin increased in osteoblasts subjected to straining in non-mineralization medium, suggesting that the mechanostress alone is a podoplanin induction factor. In osteoblasts subjected to vertical elongation straining in the mineralization ...

Biomimetic mineralization of vertical N-doped carbon nanotubes is demonstrated as a straightforward route for carbon-based mineral nanocomposites. The N-doped sites along the carbon nanotube backbone play the role of nucleation sites for mineralization.

the nasirabad manganese deposit is located 5 km south of nasirabad, 8 km sw of neyriz in the fars province. structurally, the area is placed in the southeastern part of zagros thrust belt. in this area, the manganese mineralization occurred as ore layers and nodules, interlayered with pichakun radiolarite chert deposits. in this study, mineralogy and geochemistry of uranium, thorium and lead is...

The fate and transport of 2,4-dichlorophenoxyacetic acid (2,4-D) in the subsurface is affected by a complex, time-dependent interplay between sorption and mineralization processes. 2,4-D is biodegradable in soils, while adsorption/desorption is influenced by both soil organic matter content and soil pH. In order to assess the dynamic interactions between sorption and mineralization, 2,4-D miner...