Studies involving the metabolism of chemical carcinogens were important in the discovery and initial characterization of the cytochrome P-450 enzyme system. The Millers and their associates identified NADPH-dependent microsomal enzymes involved in the biotransformation of azo dyes (1, 2). These reactions, reduction and mixed-function oxidation, were also found to be important in the processing ...

other organs: their epidemiology and implications for clinical practice, Am Rev Respir Dis 114:187-227, 1976 3 Ashcroft T, Heppeiston AG: The optical and electron microscopic determination of pulmonary asbestos fiber concentration and its relation to the human pathological reaction. J Clin Path 28:224-234, 1973 4 Smoking and Health: A report of the Surgeon General. Washington, D.C., US Departme...

.1 tlcvice is describetl ~vhich effects a continuous separatior~ of intcrnally infestetl wllcat from sound shea at, and ~11ic11 separates ~vheat into a number of fractions of different test weight. A stream of wheat, projected into still air by rapidly moving belts, is dispersed by the conlbined effects of air drag and gravitation into numerous fractions which are caught in a series of hoppers....

Analyses for test weight, 500-kernel weight, protein content, ash content, and hardness characteristics of fractions ot 13 samples of hard red winter wheat, obtained b>spectrometric separation, revealeci high negatile correlations in most cases between plumpness factors and protein and ash contents, and high positive correlations between plumpness factors and hardness, when the latter is determ...

Two cohorts of chrysotile miners and millers in Quebec were selected to study the extent to which chest radiographs taken while still employed predict mortality. The paper presents mainly findings in much the larger cohort, which consisted of 4559 men (two-thirds past workers) whose latest radiograph had been assessed by one of six experienced readers into what became the UICC/Cincinnati (U/C) ...

The authors thank Dr Raymond J. Proudlock for his comments on their article. First, studies on the genotoxicity of lead salt are inconclusive. Pelclova et al. (1) did not detect a significant increase in structural aberrations (chromosome and chromatid exchanges, and breaks) in 22 workers from a lead battery plant. In contrast, Vaglenov et al. (2) found a significant increase in MN frequency am...

extremely grateful to the Burroughs Wellcome Co. and to Hoffmann-La Roche Inc. for their support of my research in Tuckahoe from 1960 to 1970 and in Nutley from 1970 to the present. Looking back at the names of earlier recipients of the Clowes Award, I realize that I am the 6th Clowes Lecturer who, at one time or another in his career, has been associated with the McArdle Laboratory for Cancer ...

Grading factors associated with adverse growing conditions in Canada and the United States affect the edibility and end-use performance of common wheat. Mycotoxins are associated with fungal infections like fusarium head blight and ergot. Mycotoxins partition themselves among wheat milling products, and are relatively stable throughout wheat end-use processing. Fusarium head blight also has adv...

Once upon a time, an experimental neurobiologist was asked whether he thought there was a role for theory in neurobiology. He answered with a resounding " No. " Then he explained his reasoning for giving this answer. The irony of this story is that the experimentalist had a theory of why there was no role for theory. On a serious note, any experimental research activity, from planning an experi...

A high risk for the development of diffuse pleural mesothelioma is known to exist in various occupational settings associated with the use of asbestos.' Although a serious hazard has been recognised among asbestos miners, millers, and shipyard workers, recent evidence suggests that a high risk of mesothelioma may exist among occupational groups previously thought to be at low risk for developin...