Lumbar side bending movements coupled with extension or flexion is a known low back pain (LBP) risk factor in certain groups, for example, athletes participating in sports such as hockey, tennis, gymnastics, rowing and cricket. Previous research has shown that sagittal spinal postures influence the degree of spinal rotation, with less rotation demonstrated at end of range extension and flexion....

BACKGROUND Zibotentan (ZD4054) is a specific endothelin A (ETA) receptor antagonist being investigated for the treatment of prostate cancer. As zibotentan is eliminated by renal and metabolic routes, clearance may be reduced in patients with hepatic or renal impairment, leading to greater drug exposure. METHODS Open-label studies investigated the PK and tolerability of zibotentan in subjects ...

We provide direct evidence that Bin/Amphiphysin/Rvs (BAR) family members bend the steady state membrane architecture of organelles in intact cells. In response to inducible BAR molecular actuators, organelles exhibit distinct changes to the orientation and degree of their membrane curvature. This rapidly inducible system may offer a mechanism by which to better understand the structure-function...

We have numerically studied a liquid composed of achiral, bent-shaped molecules built tangent spheres. The system is known to spontaneously break mirror symmetry, as it forms macroscopically chiral, twist-bend nematic phase [Phys. Rev. Lett. 115, 147801 (2015)]. Here, we examined the full diagram such and observed several phases characterized by orientational and/or translational ordering molec...

Magnetic poly (D,L-lactide-co-glycolide) (PLGA)/lipid nanoparticles (MPLs) were fabricated from PLGA, L-α-phosphatidylethanolamine (DOPE), 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-amino (polyethylene glycol) (DSPE-PEG-NH2), and magnetic nanoparticles (NPs), and then conjugated to trans-activating transcriptor (TAT) peptide. The TAT-MPLs were designed to target the brain by magnetic gui...

Optimal Design of 60-Degree Bend in Two Dimensional Photonic Crystal Waveguides L. Dekkiche1 ∗ and R. Naoum2 113, Rue Maarouf Larbi, Sidi bel Abbes 22000, Algeria 2Laboratoire de Télécommunications et Traitement Numérique du Signal, département d’électronique, Faculté des Sciences de l’Ingénieur, Université Djillali Liabes de Sidi Bel Abbés, Algérie, 08 rue Saad Ibn Rabie cité Béni Ammeur Sidi ...